Augmentin 625 mg 10 tablets

Tradename

Augmentin

Augmentin

Structure:

each tablet contains 500 mg of amoxicillin and 125 mg of clavulanic acid

Auxiliary components:

magnesium stearate, sodium starch glycolate (type A), colloidal anhydrous silicon dioxide, microcrystalline cellulose;

Properties

Amoxicillin is a semi-synthetic penicillin (beta-lactam antibiotic) that inhibits one or more enzymes (known as penicillin-binding proteins) in the biosynthesis of bacterial peptidoglycan, which is the unifying structural component of the bacterial cell wall. Inhibition of peptidoglycan synthesis leads to a thinning of the cell wall, which subsequently leads to lysis and cell death. Amoxicillin is destroyed by the action of lactamases produced by resistant bacteria, and therefore the spectrum of activity of amoxicillin itself does not include microorganisms that produce these enzymes.

Clavulanic acid is a lactamase inhibitor structurally related to penicillins. Clavulanic acid blocks the action of certain lactamase enzymes, thereby preventing the inactivation of amoxicillin. Clavulanic acid alone does not exhibit a clinically significant antibacterial effect.

Indications

Augmentin is indicated for the treatment of the following infections in adults and children:

• Acute bacterial sinusitis

• Acute otitis media

Contraindications

a history of hypersensitivity to amoxicillin, clavulanic acid, other components of the drug, beta-lactam antibiotics (for example, penicillins, cephalosporins);

previous episodes of jaundice or liver dysfunction when using a combination of amoxicillin with clavulanic acid in history. impaired renal function (Cl creatinine less than 30 ml / min);

Precautions:

Side effects

Infectious and parasitic diseases: often — candidiasis of the skin and mucous membranes.

From the gastrointestinal tract:

— adults: very often — diarrhea; often — nausea, vomiting;