Antopral 20 mg 14 tablets

Tradename

Antopral

Antopral

Structure:

Each tablet contains: 20mg pantoprazole

Auxiliary components:

Calcium stearate, microcrystalline cellulose, crospividone, hiprolos, sodium carbonate, anhydrous silicon, anhydrous colony.

Properties

It has antibacterial activity against Helicobacter pylori and contributes to the manifestation of the anti-Helicobacter effect of other drugs. The MIC is 128 mg / l. The therapeutic effect after a single dose comes quickly and lasts for 24 hours. Provides a rapid reduction in symptoms and healing of duodenal ulcers. When taken in a dose of 40 mg, pH values> 3 persist for more than 19 hours. After 2 weeks of treatment (40 mg daily), complete healing of the duodenal ulcer is observed in 89% of patients. After 4 weeks of treatment (40 mg), 88% of patients experience complete healing of the gastric ulcer. The recurrence rate of peptic ulcers after treatment is 55%. Within 4 weeks of treatment at a dose of 40 mg / day provides complete remission in 82% of patients with gastroesophageal reflux disease stage II-III (according to Savary-Miller), after 8 weeks — in 92%. Complete endoscopic remission in 57% of children 6–13 years old with gastroesophageal reflux disease stage Ic / II (according to Vandeplas) is achieved after 4 weeks of therapy at a dose of 20 mg / day. During 4–8 weeks of treatment, the plasma gastrin level increases 1.5 times. Maintenance therapy (40–80 mg daily for more than 3 years) in patients with peptic ulcer disease was accompanied by a slight increase in the number of enterochromaffin-like (ECL-) cells.

Experimental studies of carcinogenicity indicate that long-term use of pantoprazole is associated with an increased risk of ECL cell hyperplasia and the occurrence of gastric carcinoid, liver adenoma and carcinoma, and neoplastic processes in the thyroid gland.

Indications

Peptic ulcer of the duodenum or stomach in the acute phase, incl. associated with taking NSAIDs, or refractory to therapy with histamine H2-receptor blockers; gastroesophageal reflux disease (moderate to severe); Zollinger-Ellison syndrome; combined anti-Helicobacter pylori eradication therapy in patients with peptic ulcer in order to reduce the frequency of relapses.

Mode of application:

Inside, before meals (usually before breakfast), with the required amount of water. The tablets should be swallowed whole without chewing.

Contraindications

Hypersensitivity to pantoprazole, benzimidazole derivatives or other components of the drug. Concomitant use of atazanavir. Due to insufficient data, the use of pantoprazole for the treatment of children under 12 years of age is not recommended.

Carefully:

pregnancy, lactation, liver failure.

Side effects

About 5% of patients may experience side effects from the drug.

The most common side effects: diarrhea and headache — occur in about 1% of patients.

The following undesirable side effects of pantoprazole have been reported: