Diamicron MR 60 mg 30 tablets

Trade name:

Diamicron MR

Composition

Each tablet contains:

Gliclazide 60 mg

Auxiliary components:

Calcium hydrogen phosphate dihydrate, maltodextrin, hypromelose, magnesium stearate, microcrystalline cellulose

Properties

Oral hypoglycemic agent, sulfonylurea derivative of the second generation. Stimulates insulin secretion by ß-cells of the pancreas. Increases the sensitivity of peripheral tissues to insulin. Apparently, it stimulates the activity of intracellular enzymes (in particular, muscle glycogen synthetase). Reduces the time from the moment you eat to the start of insulin secretion. Restores the early peak of insulin secretion, reduces the postprandial peak of hyperglycemia.

Gliclazide reduces platelet adhesion and aggregation, slows down the development of a parietal thrombus, and increases vascular

fibrinolytic activity. Normalizes vascular permeability. It has antiatherogenic properties: it lowers the concentration of total cholesterol (CS) and LDL-C in the blood, increases the concentration of HDL-C, and also reduces the amount of free radicals. Prevents the development of microthrombosis and atherosclerosis. Improves microcirculation. Reduces the sensitivity of blood vessels to adrenaline.

Indications

Diabetes mellitus type 2 with insufficient effectiveness of diet therapy, physical activity and weight loss.

Prevention of complications of type 2 diabetes mellitus: reducing the risk of microvascular (nephropathy, retinopathy) and macrovascular complications (myocardial infarction, stroke).

Method of administration and dosage:

Contraindications

Type 1 diabetes mellitus (insulin dependent), ketoacidosis, diabetic precoma and coma, severe renal and / or hepatic failure; pregnancy, breastfeeding period; children and adolescents up to 18 years old; hypersensitivity to sulfonylurea derivatives and sulfonamides. Simultaneous use of gliclazide and imidazole derivatives (including miconazole).

Precautions:

Gliclazide is used to treat non-insulin dependent diabetes mellitus in combination with a low-calorie, low-carbohydrate diet.

Side effects

From the digestive system: rarely — anorexia, nausea, vomiting, diarrhea, epigastric pain.

From the hematopoietic system: in some cases — thrombocytopenia, agranulocytosis or leukopenia, anemia (usually reversible).

From the endocrine system: in case of overdose — hypoglycemia.