Altiazem 60 mg 40 tablets

Tradename

Altiazem

Altiazem

Composition

Each tablet contains:

Diltiazem hydrochloride 60 mg.

Auxiliary components:

Lactose, hydrogenated castor oil, polyethylene glycol 6000, magnesium stearate.

Properties

Selective class Ill calcium channel blocker, benzodiazepine derivative. It has antianginal, hypotensive and antiarrhythmic effects. Reduces myocardial contractility, slows down AV conduction, decreases heart rate, reduces myocardial oxygen demand, expands coronary arteries, increases coronary blood flow. Reduces the tone of smooth muscles of peripheral arteries and OPSS.

Reduces the intracellular content of calcium ions in cardiomyocytes and smooth muscle cells of blood vessels, decreases heart rate, may have a slight negative inotropic effect, increases coronary, cerebral and renal blood flow. At concentrations at which there is no

negative inotropic effect, it causes relaxation of the smooth muscles of the coronary vessels and dilation of both large and small arteries.

Indications

Prevention of angina attacks. Arterial hypertension. Prevention of supraventricular arrhythmias.

Method of administration and dosage:

When administered orally, the initial dose is 60 mg 3 times / day or 90 mg 2 times / day. With insufficient effectiveness, the dose is increased to 360 mg per day.

Contraindications

Severe bradycardia, AV block Il and Ill degree (except for patients with a pacemaker), SSSU, cardiogenic shock, atrial fibrillation in WPW and Laun-Ganogh-Levin syndrome, myocardial infarction with congestion in the lungs, arte hypotension, chronic heart failure 11B -Ill sta acute heart failure, hemodynamically significant aortic stenosis, impaired liver and

kidney function, pregnancy, lactation, hypersensitivity to benzothiazepine derivatives.

Precautionary measures:

Side effects

From the side of the central nervous system and peripheral nervous system: headache, dizziness, fainting, fatigue, asthenia, sleep disturbances, drowsiness, anxiety.

From the side of the cardiovascular system: asymptomatic decrease in blood pressure; rarely — angina pectoris, arrhythmia.

From the digestive system: dry mouth, increased appetite, nausea, vomiting,