Arthfree 20 mg 30 tablets

Tradename

Arthfree

Composition

Each tablet contains:

Leflunomide 20 mg

Auxiliary components:

Lactose monohydrate, starch, colodial silicone dioxide, talc, magnesium stearate.

Properties

An agent with antiproliferative, immunosuppressive and anti-inflammatory effects. The active metabolite of leflunomide A771726 inhibits the enzyme dehydroorotate dehydrogenase and has an antiproliferative effect. A771726 in vitro inhibits mitogeninduced proliferation and DNA synthesis of Tlymphocytes.

The therapeutic effect of leflunomide has been shown in several experimental models of autoimmune diseases, including rheumatoi arthritis.

Indications

Basic therapy for rheumatoid arthritis in order to reduce the symptoms of the disease and delay the development of structural damage to the joints.

Active form of psoriatic arthritis.

Method of administration and dosage:

Contraindications

Liver dysfunctions, severe immunodeficiency states (including AIDS); — severe disorders of bone marrow hematopoiesis or anemia, leukopenia, thrombocytopenia as a result of other causes (except for rheumatoid arthritis), severe infections, moderate or severe renal failure (due to little experience of clinical observations), severe hypoproteinemia (including with nephrotic syndrome), pregnancy, lactation, children and adolescence up to 18 years, hypersensitivity to leflunomide.

Precautionary measures:

Application is possible only after a thorough medical examination of the patient.

Side effects

From the side of the cardiovascular system: often — increased blood pressure.

From the digestive system: often — diarrhea, nausea, vomiting, anorexia, lesions of the oral mucosa (aphthous stomatitis, ulceration of the lips), pain in the abdominal cavity, increased levels of liver enzymes (especially ALT, less often — GGT, alkaline phosphatase, bilirubin);

From the musculoskeletal system: often tendovaginitis; possible — ligament rupture.