Avodart 0.5 mg capsules
Trade name:
Avodart
Avodart
Composition
Each capsule contains:
Dutasteride 0.5 mg
Auxiliary components:
glycerin monocaprilocaprate type l, butylhydroxytoluene, gelatin, glycerol
(glycerin), methyl parahydroxybenzoate, propyl parahydroxybenzoate, titanium dioxide, iron dye yellow oxide.
Properties
An agent for the treatment of benign prostatic hyperplasia. Suppresses the activity of type 1 and type 2 5a-reductase isoenzymes, which are responsible for the conversion of testosterone to 5a-dihydrotestosterone. Dihydrotestosterone is the main androgen responsible for hyperplasia of the glandular tissue of the prostate.
The maximum effect of dutasteride on the decrease in dihydrotestosterone concentrations is dose-dependent and is observed after 1-2 weeks. after starting treatment. After 1 and 2 weeks. taking dutasteride at a dose of 0.5 mg / day, the mean serum dihydrotestosterone concentrations are reduced by 85% and 90%.
Dutasteride helps to shrink the prostate gland, improve urination and reduce the risk of acute urinary retention and the need for surgery.
Indications
Treatment and prevention of progression of benign prostatic hyperplasia.
Method of administration and dosage:
The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.
Contraindications
Hypersensitivity to dutasteride and other 5 reductase inhibitors; use in women and children is contraindicated.
Precautionary measures:
It should be used with caution in patients with impaired liver function. dutasteride undergoes intense metabolism in the liver, and its Tl / 2 is 3-5 weeks.
Side effects
From the reproductive system: erectile dysfunction, change (decrease) in libido, impaired ejaculation, gynecomastia (includes tenderness and enlargement of the mammary glands).
Allergic reactions: rash, itching, urticaria, localized edema, angioedema.
On the part of the skin and subcutaneous fat: alopecia (mainly loss of body hair) or hypertrichosis.