Amrizole 125 mg/ 5 ml suspension 120ml

Tradename

Amrizol

Amrizole

Composition

Each 5 ml of suspension contains:

Benzyl metronidazole 200 mg

ORAn

Auxiliary components:

Sodium phosphate monobasic, methyl parahydroxy benzoate, propyl parahydroxy benzoate, aluminum magnesium silicate, sucrose, banana flavor, glycerol, ethanol, sodium carboxymethylcellulose, purified water.

Properties

Antiprotozoal and antimicrobial drug derived from 5-nitroimidazole.

The mechanism of action consists in the biochemical reduction of the 5-nitro group by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5nitro group interacts with deoxyribonucleic acid (DNA) of microbial cells, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.

Indications

Protozoal infections: extraintestinal amebiasis, including amoebic liver abscess, intestinal amebiasis (amoebic dysentery), trichomoni (including trichomonas vaginitis, trichomonas urethritis). Infections caused by Bacteroides

spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus):

infections of bones and joints, infections of the central nervous system (CNS), incl. meningitis, brain abscess, bacterial endocarditis, pneumonia, empyema and lung abscess, sepsis. Infections caused by the species Clostridium spp., Peptococcus niger and Peptostreptococcus spp .: infections of the abdominal cavity (peritonitis, liver abscess), infections of the pelvic organs (endometritis, abscess of the fallopian tubes and ovaries, infections of the vaginal vault).

Contraindications

Hypersensitivity, leukopenia (including a history), organic lesions of the central nervous system (CNS) (including epilepsy), liver failure (in the case of large doses), pregnancy (l trimester), lactation.

With care: pregnancy (Il-Ill trimesters), renal / hepatic failure.

Precautionary measures:

Side effects

From the digestive system: diarrhea, anorexia, nausea, vomiting, intestinal colic, constipati «metallic» taste in the mouth, dry mouth, glossitis, stomatitis, pancreatitis.

From the nervous system: dizziness, impaired coordination of movements, ataxia, confusion, irritability, depression, increased excitability, weakness, insomnia, headache, convulsions, hallucinations, peripheral neuropathy.

Allergic reactions: urticaria, skin rash, skin flushing, nasal congestion, fever, arthralgia.