Flagyl 125 mg / 5 ml 100 ml suspension

Tradename

Flagil

Flagyl

Compound:

Each 100 ml of suspension contains:

Metronidazole benzoate 4.000 g.

Auxiliary components:

Ethanol, sucrose, methyl parahydroxybenzoate, propyl parahydroxybenzoate, lemon oil concentrate, purified water.

Properties

Antiprotozoal and antimicrobial drug derived from 5-nitroimidazole.

The mechanism of action consists in the biochemical reduction of the 5-nitro group by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group interacts with deoxyribonucleic acid (DNA) of microbial cells, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.

Active against Trichomonas vaginalis, Entamoeba histolytica, as well as gram-negative anaerobes Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp. and some gram-positive anaerobes (sensitive strains Eubacterium spp., Clostridium spp., Peptococcus niger., Peptostreptococcus spp.). The minimum inhibitory concentration for these strains is 0.125-6.25 μg / ml.

Indications

Protozoal infections: extraintestinal amebiasis, including amoebic liver abscess, intestinal amebiasis (amoebic dysentery), trichomoniasis (including trichomonas vaginitis, trichomonas urethritis). Infections caused by Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus): infections of bones and joints, infections of the central nervous system (CNS), incl. meningitis, brain abscess, bacterial endocarditis, pneumonia, empyema and lung abscess, sepsis. Infections caused by the species Clostridium spp., Peptococcus niger and Peptostreptococcus spp .: infections of the abdominal cavity (peritonitis, liver abscess), infections of the pelvic organs (endometritis, abscess of the fallopian tubes and ovaries, infections of the vaginal vault). Pseudomembranous colitis (associated with the use of antibiotics). Gastritis or duodenal ulcer associated with Helicobacter pylori. Prevention of postoperative complications (especially interventions on the colon, near-rectal region, apendectomy, gynecological operations). Radiation therapy for patients with tumors — as a radiosensitizing agent, in cases where tumor resistance is due to hypoxia in tumor cells.

Method of administration and dosage:

With amebiasis inside

Contraindications

Hypersensitivity.

Precautionary measures:

Long-term treatment is desirable under the control of the blood count. A false positive Nelson test is possible, since treponemas are immobilized. Combine with caution with indirect anticoagulants, non-depolarizing muscle relaxants. During treatment, the use of alcoholic beverages should be excluded.

Side effects

Nausea, metallic taste in the mouth, anorexia, epigastric pain, vomiting, diarrhea, headache, dizziness, allergic reactions (urticaria, itching), leukopenia, peripheral neuropathies, with long-term treatment with large doses, brown-reddish coloration of urine is possible.

Storage method:

At a temperature not higher than 25 C.