Concor Plus 10 mg 30 tablets

Tradename

Concor plus

Concor plus

Compound:

Each tablet contains:

Bisoprolol fumarate 10 mg

Hydrochlorothiazide 25 mg

Auxiliary components: calcium hydrogen phosphate, microcrystalline cellulose, pregelatinized starch, colloidal silicon dioxide, magnesium stearate.

Properties

Bisoprolol is a selective beta1-blocker without intrinsic sympathomimetic and membrane-stabilizing activity. It has antihypertensive, antiarrhythmic and antianginal effects. Blocking in low doses beta1-adrenergic receptors of the heart, reduces the formation of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP) stimulated by catecholamines, reduces the intracellular flow of calcium ions, has a negative chrono-, dromo-, batmo- and inotropic effect (slows down the heart rate ), inhibits cardiac conduction, reduces excitability and myocardial contractility). When the dose is increased, it blocks beta2-adrenergic receptors.

Hydrochlorothiazide is a thiazide diuretic. Reduces the reabsorption of sodium ions in the cortical segment of the loop of Henley, without affecting its section passing in the medulla of the kidneys. Blocks carbonic anhydrase in the proximal part of the convoluted renal tubules, enhances the excretion of potassium ions, bicarbonates and phosphates by the kidneys. Virtually no effect on the acid-base state. Enhances the excretion of magnesium ions by the kidneys; retains calcium ions in the body and inhibits the excretion of urates. The diuretic effect develops after 1-2 hours, reaches a maximum after 4 hours, the duration of the antihypertensive effect lasts for a day. The diuretic effect decreases with a decrease in the glomerular filtration rate and stops when its value is less than 30 ml / min.

Indications

— arterial hypertension of mild and moderate severity.

Method of administration and dosage:

Inside, in the morning (during meals), without chewing with a small amount of liquid 1 time / day.

Contraindications

— severe forms of bronchial asthma;

-chronic obstructive pulmonary disease;

-cardiogenic shock;

Side effects

Often: increased fatigue, dizziness, headache, which are especially frequent

they disappear at the beginning of treatment, are mild and disappear during the first 1-2 weeks of treatment;

Uncommon: sleep disturbance, depression, convulsions;