Co-Tareg 320 / 12.5 mg 14 tablets

Tradename

Co-Tareg

Composition

Each tablet contains:

Valsartan 320 mg

Hydrochlorothiazide 12.5 mg

Auxiliary components:

microcrystalline cellulose, croscarmellose sodium, povidone K 25, colloidal silicon dioxide, magnesium stearate.

Properties

Combined antihypertensive drug, which includes an angiotensin Il receptor blocker and a thiazide diuretic.

Angiotensin Il is an active hormone of the RAAS and is formed from angiotensin I with the participation of ACE. Angiotensin Il binds to specific receptors located on cell membranes in various tissues. It has a wide range of physiological effects, including primarily both direct and indirect participation in the regulation of blood pressure. A potent vasoconstrictor, angiotensin Il induces a direct pressor response. In addition, it stimulates the secretion of aldosterone and promotes the retention of sodium ions.

Valsartan is an active specific angiotensin Il

Indications

Arterial hypertension (for patients for whom combination therapy is indicated).

Method of administration and dosage:

The optimal dosage regimen is determined the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.

Contraindications

Hypersensitivity to valsartan, hydrochlorothiazide and other sulfonamide derivatives; severe liver dysfunction (more than 9 points on the Child-Pugh scale); biliary cirrhosis of the liver; cholestasis; severe renal dysfunction (GFR <30 ml / min / 1.73 m2); anuria; refractory hypokalemia, hyponatremia, hypercalcemia; symptomatic hyperuricemia; simultaneous use with aliskiren or aliskirencontaining drugs in patients with diabetes mellitus and / or moderate or severe renal impairment (GFR less than 60 ml / min / 1.7 m2); pregnancy and pregnancy planning; lactation period (breastfeeding); children under

18 years of age (the effectiveness and safety of the drug in this category of patients have not yet been established).

Precautions:

Side effects

From the side of metabolism: infrequently — a decrease in the BCC.

From the nervous system: often — headache; infrequently — paresthesia; very rarely dizziness; frequency unknown — syncope.

From the side of the organ of vision: infrequently — decreased visual acuity.