Curam 642.9 mg / 5 ml powder for suspension preparation 75 ml

Trade name:

Curam

Composition

Each 5 ml of suspension contains:

amoxicillin (in the form of amoxicillin trihydrate)

600 mg

clavulanic acid (as potassium clavulanate) 4mg

Auxiliary components:

xanthan gum, aspartame, succinic acid, colloidal silicon dioxide, hypromellose, orange flavor, caramel flavor, silicon dioxide.

Properties

Amoxicillin is a semisynthetic broad-spectrum antibiotic with activity against many grampositive and gram-negative microorganisms. At the same time, amoxicillin is subject to destruction by ß-lactamases, and therefore the spectrum of activity of amoxicillin does not extend to microorganisms that produce this enzyme.

Clavulanic acid, a ß-lactamase inhibitor, structurally related to penicillins, has the ability to inactivate a wide range of ß-lactamases found in microorganisms resistant to penicillins and cephalosporins. Clavulanic acid is sufficiently effective against plasmid ßlactamases, which most often cause bacterial resistance, and less effective against chromosomal type 1 ß-lactamases, which a not inhibited by clavulanic acid.

The presence of clavulanic acid in Kuram@ protects amoxicillin from destruction by enzymes — ß-lactamases, which makes it possible to expand the antibacterial spectrum of amoxicillin.

Indications

Bacterial infections caused by microorganisms susceptible to the drug: infections of the upper respiratory tract and ENT organs (for example, recurrent tonsillitis, sinusitis, otitis media), usually caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pyogenes; lower respiratory tract infections: exacerbations of chronic bronchitis, lobar pneumonia and bronchopneumonia, usually caused by Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis; infections of the genitourinary tract: cystitis, urethritis, pyelonephritis, infections of the female genital organs, usually caused by species of the family Enterobacteriaceae (mainly Escherichia coli), Staphylococcus saprophyticus and species of the genus Enterococcus; gonorrhea due to Neisseria gonorrhoeae; infections of the ski and soft tissues, usually caused by Staphylococcus aureus, Streptococcus pyogenes and Bacteroides species; bone and joint infections (eg, osteomyelitis, usually caused by Staphylococcus aureus); if necessary, long-term therapy.

Method of administration and dosage:

The drug is taken orally.

Contraindications

-Hypersensitivity to amoxicillin, clavulanic acid, other components of the drug, beta-lactam antibiotics (for example, penicillins, cephalosporins) in history;

previous episodes of jaundice or impaired liver function when using a combination of amoxicillin with clavulanic acid in history;

-Children up to 3 months (for powder for preparation of oral suspension 200 mg / 28.5 mg in 5 ml and 400 mg / 57 mg in 5 ml);

Side effects

Infectious and parasitic diseases: often candidiasis of the skin and mucous membranes.

From the hematopoietic system: rarely reversible leukopenia (including neutropenia) and reversible thrombocytopenia; very rarely reversible agranulocytosis and reversible hemolytic anemia, prolongation of prothrombin time and bleeding time, anemia, eosinophilia, thrombocytosis.

From the immune system: very rarely anqioedema, anaphylactic reactions, a syndrome similar to serum sickness, allergic vasculitis.