Septazole 200 tablets

Tradename

Septazole

Septazole

Composition

Each tablet contains:

Sulfamethoxazole 400 mg

Trimethoprim 80 mg

Auxiliary components:

potato starch, talc, magnesium stearate, polyvinyl alcohol.

Properties

Combined antibacterial drug containing sulfamethoxazole and trimethoprim.

Sulfamethoxazole, similar in structure to PA disrupts the synthesis of dihydrofolic acid i bacterial cells, preventing the incorporation of PABA into its molecule.

Trimethoprim enhances the effect of sulfamethoxazole, disrupting the reduction of dihydrofolic acid to tetrahydrofolic acid, the active form of folic acid, which is responsible for protein metabolism and microbial cell division.

Indications

Treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

respiratory tract infections (including bronchitis, pneumonia, lung abscess, pleura empyema);

and / or in chronic infections, a single dose may be increased by 30-50%.

Contraindications

an established diagnosis of damage to the liver parenchyma;

severe renal dysfunction in the absence of the ability to control the concentration of the drug in the blood plasma;

severe renal failure (CC less than 15 ml / min);

Side effects

The drug is generally well tolerated.

From the nervous system: headache, dizziness; in some cases — aseptic meningitis, depression, apathy, tremor, peripheral neuritis.

From the respiratory system: bronchospasm, dyspnea, cough, pulmonary infiltrates.