Adankor 10 mg 30 tablets

Tradename

Adankor

Composition

Each tablet contains:

Nicorandil 10 mg or 20 mg

Auxiliary components:

potato starch, microcrystalline cellulose type 102, calcium stearate.

Properties

Antianginal agent, has nitrate-like properties and the ability to open potassium channels.

Due to the opening of potassium channels, nicorandil causes hyperpolarization of the cell membrane, and the nitrate-like effect is to increase the intracellular content of cyclic guanyl monophosphate. These pharmacological effects lead to relaxation of smooth muscle cells and provide a protective effect on cardiomyocytes during ischemia.

The hemodynamic effects are expressed in a balanced decrease in pre- and afterload, in contrast to nitrates and slow calcium channel blockers, which act mainly on pre- and afterload, respectively. Taking into account the selective vasodilation of the coronary arteri as a result, the load on the ischemic myocardium is minimal. Nicorandil does not affect myocardial contractility, practically does

Indications

Relief of angina attacks; prevention of attacks of stable angina pectoris (in combination with other antianginal drugs) and as monotherapy for intolerance to beta-blockers and blockers of slow calcium channels.

Method of administration and dosage:

Is taken internally. The dose is set individually, depending on the severity and duration of the disease. Single dose — 10-20 mg, frequency of use — 1-3 times / day. The maximum daily d is 80 mg.

Contraindications

Acute myocardial infarction (and within 3 months after); cardiogenic shock, collapse; unstable angina, incl. Prinzmetal’s angina; chronic heart failure of Ill or IV functional class according to NYHA classification; severe bradycardia (heart rate less than 50 beats / min); AV block Il and Ill degree; left ventricular failure with low filling pressure; severe arterial hypotension (diastolic blood pressure at rest less than 100 mm Hg); severe anemia; refractory hyperkalemia; concomitant use of PDE5 inhibitors (sildenafil, vardenafil, tadalafil); pregnancy, lactation (breastfeeding); children and adolescents up to 18 years old.

Precautionary measures:

It should be used with caution in patients with cardiac arrhythmias, with impaired renal and / or liver function, hypovolemia, arterial hypotension, pulmonary edema, angle-closure glaucoma, hyperkalemia, 1st degree AV blo and hyperthyroidism.

Side effects

From the side of the cardiovascular system: palpitations, tachycardia, decreased blood pressure, postural hypotension, flushing to the skin of the face, peripheral edema. When using nicorandil in a high dose, arterial hypotension and / or tachycardia is possible.

From the side of the central nervous system: headache, dizziness, tinnitus, insomnia.

From the digestive system: nausea, vomiting, discomfort in the stomach, a feeling of fullness in the stomach, stomatitis (extremely rare); in some cases — an increase in the activity of ALT, AST, ALP.