Duphaston 10 mg 60 tablets

Trade name:

Duphaston

Duphaston

Composition

Each tablet contains:

Dydrogesterone 10 mg

Auxiliary components:

lactose monohydrate, hypromellose, corn starch, colloidal silicon dioxide, magnesium stearate.

Properties

An analogue of natural progesterone. Dydrogesterone in its molecular structure, chemical and pharmacological properties is very close to natural progesterone. Due to the fact that dydrogesterone is not a derivative of testosterone, it does not have the side effects that are characteristic of most synthetic progestogens, the so-called «androgenic» progestogens. Dydrogesterone does not ha estrogenic, androgenic, anabolic, glucocorticoid and thermogenic activity.

As a progestogenic component of HRT in menopause, dydrogesterone helps to maintain the beneficial effect of estrogens on the lipid profile of the blood. However, unlike estrogens, which usually negatively affect the blood coagulation system, dydrogesterone does not affect coagulation parameters. Does not adversely affect carbohydrate metabolism and liver function. Dydrogesterone, when administered orally, selectively affects the endometrium, thereby preventing an increased risk of endometrial hyperplasia and / or carcinogenesis in conditions of excess estrogen. It is indicated in all cases of endogenous progesterone deficiency.

Dydrogesterone has no contraceptive effect. When treating with dydrogesterone, the therapeutic effect is achieved without suppressing ovulation or disturbing menstrual function. Dydrogesterone makes conception and maintenance of pregnancy possible during treatment.

Indications

Progesterone deficiency: endometriosis; infertility due to luteal insufficiency; threatening or habitual miscarriage (with progesterone deficiency); premenstrual tension syndrome; dysmenorrhea, irregular menstrual cycle; secondary amenorrhea (in combination therapy with estrogens); dysfunctional uterine bleeding.

HRT: to neutralize the proliferative effect of estrogens on the endometrium in women with disorders caused by natural or surgical menopause with an intact uterus.

Method of administration and dosage:

Contraindications

Hypersensitivity to dydrogesterone; diagnosed or suspected progestogen-dependent neoplasms (eg, meningioma); bleeding fro the vagina of unclear etiology; liver dysfunctions caused by acute or chronic liver diseases at the present time or in history

(before the normalization of liver function tests); current or history of malignant liver tumors; period of breastfeeding; current or history of porphyria; age up to 18 years.

When combined with estrogens (HRT):

Side effects

From the hematopoietic system: rarely hemolytic anemia.

From the nervous system: often — migraine / headache; infrequently — dizziness; rarely, drowsiness.

From the side of the psyche: infrequently depressed mood.