Septrin DS 10 tablets

Tradename

Septrine

Septrin

Composition

Each tablet contains:

Trimethoprim 160 mg

Sulfamethoxazole 800 mg

Auxiliary components:

potato starch, talc, magnesium stearate, polyvinyl alcohol.

Properties

Combined antibacterial drug containing sulfamethoxazole and trimethoprim.

Sulfamethoxazole, similar in structure to PABA, disrupts the synthesis of dihydrofolic acid in bacterial cells, preventing the incorporation of PABA into its molecule.

Trimethoprim enhances the effect of sulfamethoxazole, disrupting the reduction of dihydrofolic acid to tetrahydrofolic acid, the active form of folic acid, which is responsible for protein metabolism and microbial cell division.

Indications

Treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

respiratory tract infections (including bronchitis, pneumonia, lung abscess, pleural empyema);

-otitis, sinusitis;

Contraindications

an established diagnosis of damage to the liver parenchyma;

severe renal dysfunction in the absence of the ability to control the concentration of the drug in the blood plasma;

severe renal failure (CC less than 15 ml / min);

Side effects

The drug is generally well tolerated.

From the nervous system: headache, dizzin in some cases — aseptic meningitis, depression,

apathy, tremor, peripheral neuritis.