Isotretinoin 20 mg 10 capsules

Tradename

Isotretinoin

Isotretinoin

Composition

Each capsule contains:

Isotretinoin 20 mg

Auxiliary components:

soybean oil, yellow beeswax, soybean oil, hydrogenated oil, soybean oil, partially hydrogenated;

capsule shell: gelatin, glycerol, Karion 83 (hydrolyzed potato starch, mannitol, sorbitol), canthaxanthin, titanium dioxide; ink for the inscription on the capsule (shellac, iron oxide black oxide).

Properties

Isotretinoin is a stereoisomer of trans retinoic acid (tretinoin). The exact mechanism of action of the drug has not yet been elucidated, but it has been established that the improvement in the clinical picture of severe forms of acne is associated with the suppression of the activity of the sebaceous glands and a histologically confirmed decrease in their size. In addition, the anti-inflammatory effect of isotretinoin on the skin has been proven.

Hyperkeratosis of epithelial cells of the hair follicle and sebaceous gland leads to desquamation of corneocytes into the duct of the gland and to blockage of the latter with keratin and excess sebaceous secretion. This is followed by the formation of a comedone and, in some cases, the addition of an inflammatory process. Isotretinoin inhibits the proliferation of sebocytes and acts on acne, restoring the normal process of cell differentiation. Sebum is the main substrate for the growth of

Propionibacterium acnes, therefore, reducing sebum production inhibits bacterial colonization of the duct.

Indications

Severe acne (nodular-cystic, conglobatic acne, or acne with risk of scarring).

Acne that does not respond to other therapies.

Method of administration and dosage:

Contraindications

-pregnancy, planned or established (possibly embryotoxic and teratogenic effects), the period of breastfeeding, hypervitaminosis A, liver failure, concomitant treatment with tetracyclines, severe hyperlipidemia; additionally for rectal use: rectal pathology; for local use: it is not recommended to apply the drug to large areas of the skin during pregnancy, breastfeeding and women planning pregnancy.

Precautions:

Restrictions on use.

Side effects

Sensory organs and nervous system: headache, excessive fatigue, seizures, increased intracranial pressure (pseudotumor of the brain: nausea, headache, vomiting, optic nerve edema, visual impairment), xerophthalmia, photophobia, isolated cases of visual impairment.

Digestive system: bleeding from the gums, dryness of the oral mucosa, bleeding, inflammation of the gums, diarrhea, nausea, inflammatory bowel disease (ileitis, colitis), pancreatitis.

Hypervitaminosis A: dryness of mucous