Lasix 40 mg 24 tablets

Tradename

Lasix

Composition

Each tablet contains:

Furosemide 40 mg

Auxiliary components:

Lactose monohydrate, starch, talc, magnesium stearate.

Properties

«Loop» diuretic; causes a fast, strong and short-term diuresis. Blocks the reabsorption of sodium and chlorine ions both in the proximal and in the distal parts of the renal tubules and in the thick segment of the ascending part of the Gentle loop. Furosemide has a pronounced diuretic, natriuretic and chloruretic effect. Due to the increase in the release of sodium ions, there is a secondary (mediated by osmotically bound water) enhanced excretion of water and an increase in the secretion of potassium ions in the distal part of the renal tubule. At the same time, the excretion of calcium and magnesium ions increases. Has secondary effects due to the release of intrarenal mediators and the redistribution of intrarenal blood flow. Against the background of the course of treatment, there is no weakening of the effect.

After oral administration of 40 mg of furosemide, the diuretic effect begins within 60 minutes and lasts about 3-6 hours (with reduced renal function — up to 8 hours). During the period of action, the excretion of sodium ions increases significantly, however, after its termination, the rate of excretion decreases below the initial level («rebound» or

«cancellation» syndrome). The phenomenon is caused by a sharp activation of the reninangiotensin-aldosterone system and other anti-natriuretic neurohumoral regulation links in response to massive diuresis; stimulates the arginine-vasopressive and sympathetic systems. Reduces the level of atrial natriuretic factor in blood plasma, causes vasoconstriction. Due to the «rebound» syndrome, when taken 1 time / day, it may not cause a significant effect on the daily release of sodium ions and blood pressure.

Indications

Edematous syndrome:

with chronic heart failure;

with chronic renal failure;

Contraindications

-Acute renal failure with anuria;

-severe hepatic failure, «hepatic» coma and precoma;

-Acute glomerulonephritis, pronounced disorders of the outflow of urine of any etiology (including unilateral urinary tract damage), hyperuricemia;

Side effects

From the side of the cardiovascular system: a pronounced decrease in blood pressure, collapse, tachycardia, arrhythmias, a tendency to thrombosis, a decrease in circulating blood volume.

From the side of the central nervous system: dizziness, headache, muscle weakness, cramps of the calf muscles (tetany), paresthesia, apathy, weakness, weakness, lethargy, drowsiness, confusion.

From the senses: impaired vision and hearing, tinnitus.