Mayodura 10 mg 30 tablets

Tradename

Mayodura

Myodura

Compound:

Each tablet contains:

Amlodipine 10 mg

Auxiliary components:

calcium stearate, potato starch, lactose (milk sugar), magnesium stearate, microcrystalline cellulose.

Properties

A second generation slow calcium channel blocker (BMCC), a dihydropyridine derivative. It has antianginal and hypotensive effects. By binding to dihydropyridine receptors, it blocks calcium channels, reduces the transmembrane transition of calcium ions into the cell (to a greater extent in vascular smooth muscle cells than in cardiomyocytes).

The antianginal effect is due to the expansion of the coronary and peripheral arteries and arterioles: with angina pectoris, it reduces the severity of myocardial ischemia; expanding the peripheral arterioles, reduces the systemic vascular resistance; reduces preload on the heart, myocardial oxygen demand. Expands the main coronary arteries and arterioles in unchanged and ischemic zones of the myocardium, increases the flow of oxygen to the myocardium (especially with vasospastic angina); prevents the development of spasm of the coronary arteries (including those caused by smoking). In patients with angina pectoris, a single daily dose increases exercise tolerance, delays the development of the next attack of angina pectoris and ischemic depression of the ST segment; reduces the frequency of angina attacks and nitroglycerin consumption.

Amlodipine has a long-term dose-dependent hypotensive effect, which is due to a direct vasodilating effect on vascular smooth muscle. With arterial hypertension, a single daily dose of amlodipine provides a clinically significant decrease in blood pressure for 24 hours (with the patient lying and standing).

Indications

— arterial hypertension (as monotherapy or in combination with other antihypertensive drugs);

— stable exertional angina and Prinzmetal angina (as monotherapy or in combination with other antianginal drugs).

Method of administration and dosage:

Contraindications

— severe arterial hypotension (systolic blood pressure less than 90 mm Hg);

-collapse;

-cardiogenic shock;

Side effects

From the side of the cardiovascular system: often — a feeling of palpitations, peripheral edema (swelling of the ankles and feet).

From the side of the central nervous system: often — headache, dizziness, fatigue.

From the digestive system: often — nausea, abdominal pain.