Ursoplus 20 capsules

Tradename

Ursoplus

Ursoplus

Composition

Each capsule contains:

ursodeoxycholic acid 250 mg

silymarin 140 mg

Properties

Hepatoprotector. Ursodeoxycholic acid is a bile acid. Reduces cholesterol in bile mainly by dispersing cholesterol and forming a liquid crystal phase. It has an effect on the enterohepatic circulation of bile salts, reducing the reabsorption of endogenous, more hydrophobic and potentially toxic compounds in the intestine.

In vitro studies have shown that ursodeoxycholic acid has a direct hepatoprotective effect and reduces the hepatotoxicity of hydrophobic bile salts.

It has an effect on immunological reactions, reducing the pathological expression of class I HLA antigens on hepatocytes and suppressing the production of cytokines and interleukins.

Indications

Cholesterol gallstones in the gallbladder and common bile duct in patients when surgical or endoscopic treatment is not possible. Cholesterol stones of the gallbladder and common bile duct with a diameter of not more than 1.5-2 cm after extracorporeal lithotripsy or mechanical lithotripsy. Primary biliary cirrhosis (before the formation of advanced fibrosis and cirrhosis of the liver). Chronic active hepatitis with cholestatic syndrome. Acute hepatitis, cystic fibrosis of the liver, congenital atresia of the bile duct. Biliary reflux esophagitis and gastritis. Biliary dyspeptic syndrome in cholecystopathy and biliary dyskinesia. Prevention and treatment of cholestatic syndrome caused by the use of hormonal contraceptives. To normalize liver function in patients receiving therapy with cytostatics, as well as in patients with alcoholic liver damage. Liver and other organ transplantation (adjunctive treatment).

Method of administration and dosage:

The optimal dosage regimen is determined b the doctor. The compliance of the used dos form of a particular drug with indications for use and dosage regimen should be strictly

Contraindications

Hypersensitivity to silymarin.

Acute inflammatory diseases of the gallbladder and biliary tract, cirrhosis of the liver in the stage of vascular and parenchymal decompensation and / or severe activity, NUC, Crohn’s disease, severe renal dysfunction, hypersensitivity to ursodeoxycholic acid.

Precautions:

Side effects

Possibly: a transient increase in the activity of hepatic transaminases, skin itching, allergic reactions.

Rarely: diarrhea, calcification of gallstones.

Rarely: laxative effect, allergic reactions.