Vaxato 20 mg 30 tablets

Tradename

Vaxato

Composition

Each tablet contains:

Rivaroxaban 20 mg

Auxiliary components: microcrystalline cellulose, croscarmellose sodium, hypromellose 5 CP (hydroxypropyl methylcellulose 2910), lactose monohydrate, magnesium stearate, sodium lauryl sulfate.

Properties

Rivaroxaban is a highly selective direct factor Xa inhibitor with high oral bioavailability.

The activation of factor X to form factor Xa through the internal and external coagulation pathways plays a central role in the coagulation cascade. Factor Xa is a component of the forming prothrombinase complex, the action of which leads to the conversion of prothrombin to thrombin. As a result, these reactions lead to the formation of fibrin thrombus and platelet activation by thromb• One molecule of factor Xa catalyzes the formation of more than 1000 thrombin molecules, which is called the «thrombin explosion». The reaction rate of factor Xa bound in prothrombinase is increased 300,000 times compared to that of free factor Xa, which provides a sharp jump in thrombin level. Selective factor Xa inhibitors can stop the thrombin burst. Thus,

Indications

prevention of stroke and systemic thromboembolism in patients with atrial fibrillation of non-valvular origin;

treatment of deep vein thrombosis and pulmonary embolism and prevention of recurrence of DVT and PE.

Method of administration and dosage:

Contraindications

hypersensitivity to rivaroxaban or any excipients contained in the tablet;

-clinically significant active bleeding (eg, intracranial bleeding, gastrointestinal bleeding);

damage or condition associated with an increased risk of major bleeding (for exampl existing or recent gastrointestinal ulcer, presence of malignant neoplasms with a high risk of bleeding, recent brain or spinal cord injury, recent surgery on the brain, spinal cord, or eyes, recent intracranial hemorrhage, diagnosed or suspected varicose veins of the esophagus, arteriovenous malformations, vascular aneurysms or large anomalies in the structure of the vessels of the brain or spinal cord);

Side effects

anemia (including relevant laboratory parameters)

hemorrhage in the eye (including hemorrhage in the conjunctiva)

pain in the gastrointestinal tract, dyspepsia, nausea, constipation, diarrhea, vomiting, bleeding gums, gastrointestinal bleeding (including rectal bleeding)