Xanoxiban 20 mg 30tablets

Tradename

Xanoxiban

Xanoxiban

Composition

Each tablet contains:

Rivaroxaban 20 mg

Auxiliary components:

microcrystalline cellulose, croscarmellose sodium, hypromellose 5 CP (hydroxypropyl methylcellulose 2910), lactose monohydrate, magnesium stearate, sodium lauryl sulfate.

Properties

Rivaroxaban is a highly selective direct factor Xa inhibitor with high oral bioavailability.

The activation of factor X to form factor Xa through the internal and external coagulation pathways plays a central role in the coagulation cascade. Factor Xa is a component of the forming prothrombinase complex, the action of which leads to the conversion of prothrombin to thrombin. As a result, these reactions lead to the formation of fibrin thrombus and platelet activation by thromb One molecule of factor Xacatalyzes the formation of more than 1000 thrombin molecules, which is called the «thrombin explosion». The reaction rate of prothrombinase-bound factor Xa is increased 300,000-fold compared to that of free factor Xa, which provides a sharp jump in thrombin level. Selective factor Xa inhibitors can stop the thrombin burst. Thus,

Indications

— prevention of stroke and systemic thromboembolism in patients with atrial fibrillation of non-valvular origin;

-treatment of deep vein thrombosis and pulmonary embolism and prevention of recurrent DVT and PE.

Method of administration and dosage:

Contraindications

hypersensitivity to rivaroxaban or any excipients contained in the tablet;

-clinically significant active bleeding (eg, intracranial bleeding, gastrointestinal bleeding);

injury or condition associated with an increased risk of major bleeding (for example, existing or recent gastrointestinal ulcer, presence of malignant neoplasms with a high risk of bleeding, recent brain or spinal cord injury, recent surgery on the brain, spinal cord, or eyes, recent intracranial hemorrhage, diagnosed or suspected varicose veins of the esophagus, arteriovenous malformations, vascular aneurysms or large anomalies in the structure of the vessels of the brain or spinal cord);

Side effects

anemia (including relevant laboratory parameters) — hemorrhage in the eye (including hemorrhage in the conjunctiva) — pain in th gastrointestinal tract, dyspepsia, nausea, constipation, diarrhea, vomiting, bleeding gums, gastrointestinal bleeding (including

rectal bleeding) — fever , peripheral edema, deterioration of general well-being (including weakness and asthenia) — hemorrhages after performed procedures (including postoperative anemia and bleeding from a wound), bruising increased transaminase levels — pain in the extremities. — dizziness, headache — bleeding from the urogenital tract (including hematuria and nameorrhagia), renal failure (including increased creatinine levels, increased urea levels) — nosebleeds, hemoptysis — itching (including infrequent cases of generalized itching), rash, ecchymosis,skin and subcutaneous hemorrhages — arterial hypotension, hematoma.

Storage method: