Clavimox 1 g 8 tablets

Trade name:

Clavimox

Clavimox

Composition

Each tablet contains:

Amoxicillin 875mg

Clavulanic acid 125mg

Auxiliary components: colloidal silicon dioxide, crospovidone, croscarmellose sodium, magnesium stearate, microcrystalline cellulose. The composition of the film shell:

hypromellose, ethyl cellulose, polysorbate 80, triethyl citrate, titanium dioxide, talc.

Properties

Combined preparation of amoxicillin and clavulanic acid — a beta-lactamase inhibitor. Acts bactericidal, inhibits the synthesis of t bacterial wall. Active against aerobic grampositive bacteria (including strains producing beta-lactamase): Staphylococcus aureus; aerobic gram-negative bacteria: Enterobacter spp., Escherichia coli, Haemophilus influenzae, Klebsiella spp., Moraxella catarrhalis. The following pathogens are sensitive only in vitro: Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus anthracis,

Streptococcus pneumoniae, Streptococcus viridans, Enterococcus faecalis, Corynebacterium spp., Listeria monocytogenes; anaerobic Clostridium spp., Peptococcus spp., Peptostreptococcusspp .; as well as aerobic gram-negative bacteria (including strains that produce betalactamases): Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp., Bordetella pertussis, Yersinia enterocolitica,

Gardnerellavaginalis, Neisseria meningitidis,

Indications

Treatment of infectious and inflammatory diseases caused by sensitive pathogens: lower respiratory tract infections (bronchitis, pneumonia, pleural empyema, lung abscess); ENT infections (sinusitis, tonsillitis, otitis media); infections of the genitourinary system and pelvic organs (pyelonephritis, pyelitis, cystitis, urethritis, prostatitis, cervicitis, salpingitis, salpingo-oophoritis, tubo-ovarian abscess, endometritis, bacterial vaginitis, septic abortion, postpartum sepsis, pelvioperitonitis, soft chancre); infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses, abscess, phlegmon, wound infection); osteomyelitis; postoperative infections. Prevention of infections in surger

Method of administration and dosage:

Adults and children over 12 years old or weighing 40 kg or more: 500 mg 2 times / day or 250 mg 3 times / day. For severe infections and respiratory tract infections — 875 mg 2 times / day or 500 mg 3 times / day. The maximum daily dose of amoxicillin for adults and children over 12 years old is 6 g, for children under 12 years old — 45 mg / kg body weight. The maximum daily dose of clavulanic acid for adults and children over 12 years old is 600 mg, for children under 12 years old — 10 mg / kg body weight. Duration of treatment up to 14 days, acute otitis media — up to 10 days.

Contraindications

Hypersensitivity to the components of the drug (including cephalosporins and other betalactam antibiotics); infectious mononucleosis (including when a measles-like rash appears); phenylketonuria; episodes of jaundice or abnormal liver function as a result of amoxicillin / clavulanic acid use in history; CC less than 30 ml / min (for tablets 875 mg / 125 mg).

Carefully:

Pregnancy, lactation period, severe liver failure, gastrointestinal diseases (including a history of colitis associated with the use of penicillins), chronic renal failure.

Side effects

From the digestive system: nausea, vomitindiarrhea, gastritis, stomatitis, glossitis, increased activity of hepatic transaminases, in isolated cases — cholestatic jaundice, hepatitis,

liver failure (more often in the elderly, men, with prolonged therapy), pseudomembranous and hemorrhagic colitis ( can also develop after therapy), enterocolitis, black «hairy» tongue, darkening of tooth enamel.

From the side of hematopoiesis: a reversible increase in prothrombin time and bleeding time, thrombocytopenia, thrombocytosis, eosinophilia, leukopenia, agranulocytosis, hemolyticanemia.