Dufalac 667mg/ml syrup 200 ml

Tradename

Duphalac

Duphalac

Compound:

Lactulose 667 mg/ml

Auxiliary components:

citric acid, purified water up to 100 ml.

Properties

Laxative. Lactulose, a disaccharide consisting of galactose and fructose, is not hydrolyzed by disaccharidases of the small intestine mucosa. It has a hyperosmotic laxative effect, stimulates intestinal motility, improves the absorption of phosphates and calcium salts, promotes the excretion of ammonium ions.

Lactulose is broken down by the intestinal flora of the large intestine into low molecular weight organic acids, which leads to a decrease in pH and an increase in osmotic pressure and, as a result, an increase in the volume of intestinal contents. These effects stimulate intestinal motility and affect the consistency of the stool. The physiological rhythm of emptying the large intestine is restored.

In hepatic encephalopathy, the effect is attributed to the suppression of proteolytic bacteria by increasing the number of acidophilic bacteria (for example, lactobacilli), the transition of ammonia to the ionic form due to acidification of the contents of the colon; bowel movements due to a decrease in pH in the colon and an osmotic effect; as well as reducing the content of nitrogen-containing toxic substances by stimulating bacteria that utilize ammonia for bacterial protein synthesis.

Indications

Chronic constipation, as well as diseases requiring relief from bowel movements. Prevention and treatment of hepatic encephalopathy in adults.

Dosage and administration

Adults:

The usual initial (first three days) daily dose is 45 ml (3 tablespoons) of syrup taken once before breakfast or 15 ml (1 tablespoon) three times a day before meals. After achieving a therapeutic effect, a maintenance dose of 15 ml (1 tablespoon) of syrup should be taken on an empty stomach.

Children over 3 years old:

Contraindications

Hypersensitivity to lactulose; intestinal obstruction; intolerance to fructose, galactose; lactase deficiency; glucose-galactose malabsorption; galactosemia; rectal bleeding (which is not caused by hemorrhoids); suspicion of appendicitis, acute inflammatory diseases of the abdominal cavity.

With caution: diabetes mellitus, colostomy or ileostomy.

Precautionary measures:

Side effects

From the side of metabolism: very rarely — hypernatremia; the frequency is unknown — disorders of water and electrolyte metabolism that occur due to diarrhea.

From the digestive system: nausea, vomiting, abdominal pain, flatulence, diarrhea.

Storage method: