Oseltamivir 75 mg 10 capsules

Tradename

Oseltamivir

Oseltamivir

Compound:

Each capsule contains:

Oseltamivir 75 mg

Auxiliary components:

corn starch, pregelatinized starch, povidone K25, croscarmellose sodium, sodium stearyl fumarate.

Properties

Antiviral agent. It is a prodrug whose active metabolite (oseltamivir carboxylate) selectively inhibits influenza virus types A and B neuraminidase. Neuraminidase is a glycoprotein that catalyzes the cleavage of the bond between the terminal sialic acid and sugar, thereby contributing to the spread of the virus in the respiratory tract (the release of virions from the infected cell and penetration into the epithelial cells of the respiratory tract, preventing the inactivation of the virus by epithelial mucus). Oseltamivir carboxylate acts outside cells and competitively inhibits viral neuraminidase. It inhibits the growth of the influenza virus in vitro and suppresses the replication of the virus and its pathogenicity in vivo. Reduces the release of influenza A and B viruses from the body.

Does not affect the production of antibodies in response to the introduction of an inactivated influenza vaccine. The frequency of resistance of clinical isolates of the virus is 2%.

Indications

Influenza types A and B.

Dosage and administration

The optimal dosing regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed.

Taken orally, regardless of food intake.

When treating, the intake should be started no later than 2 days from the moment the symptoms of the disease develop at a dose of 75 mg 2 times / day for 5 days. Increasing the dose of more than 150 mg / day does not lead to an increase in the effect.

Contraindications

Chronic renal failure (CC less than 10 ml / min), liver failure, hypersensitivity to oseltamivir.

Precautionary measures:

Use with caution in children.

Side effects

From the digestive system: nausea, vomiting (usually when taken in high doses, or in the first days of treatment); rarely — diarrhea, abdominal pain.

From the side of the central nervous system: insomnia, dizziness, headache.

From the respiratory system: nasal congestion, sore throat, cough.