Cosopt drops 5 ml

Tradename

cosopt

Kosopt

Compound:

Each ml contains:

dorzolamide hydrochloride,

— which corresponds to the content of dorzolamide base 2%

timolol maleate

— which corresponds to the content of timolol base 0.5%

Auxiliary components:

benzalkonium chloride (as 50% benzalkonium chloride solution), sodium citrate, mannitol, hyetellose (hydroxyethylcellulose), 1M sodium hydroxide solution, water for injections.

Properties

Antiglaucoma drug of combined composition. Contains two active ingredients: dorzolamide hydrochloride and timolol maleate, each of which reduces elevated intraocular pressure by reducing the secretion of intraocular fluid. The combined action of these substances in the composition of the drug leads to a more pronounced decrease in intraocular pressure.

Dorzolamide hydrochloride is a selective type II carbonic anhydrase inhibitor. Inhibition of carbonic anhydrase in the ciliary body leads to a decrease in the secretion of intraocular fluid, presumably due to a decrease in the formation of bicarbonate ions, which in turn leads to a slowdown in the transport of sodium and fluid.

Timolol maleate is a non-selective beta-blocker. Although the exact mechanism of action of timolol maleate in reducing intraocular pressure has not yet been established, a number of studies have shown a predominant decrease in formation, as well as a slight increase in fluid outflow.

Indications

Increased intraocular pressure:

— with open-angle glaucoma;

— with pseudoexfoliative glaucoma with insufficient effectiveness of monotherapy.

Dosage and administration

Kosopt is prescribed 1 drop in the conjunctival sac of the affected eye (or both eyes) 2 times / day.

If Kosopt is prescribed as a replacement for another ophthalmic drug for the treatment of glaucoma, the latter should be discontinued the day before the start of Kosopt therapy.

In case of joint use with another topical ophthalmic preparation, Kosopt should be used at intervals of at least 10 minutes.

Contraindications

— hyperreactivity of the respiratory tract;

— bronchial asthma (including history);

— severe COPD;

Side effects

The most commonly observed side effects on the part of the organ of vision: burning sensation or itching in the eye, taste distortion, corneal erosion, conjunctival injection, blurred vision, lacrimation.

Storage method:

Store at a temperature not higher than 15-30 degrees. After opening, store no longer than 28 days.