Miconaz 2% oral gel 20 g

Trade name:

Miconaz

mikonaz

Properties

Miconazole is an imidazole antifungal agent with fungicidal and bactericidal activity against dimorphic fungi, dermatophytes and fungi of the genus Candida, including Candida albicans, Dimorphons fungi, Cryptococcus neoformans, Pityrosporum sp, Torulopsis glabrata, as well as against some gram-positive bacilli and cocci. Accordingly, Miconaz oral gel is effective in the treatment of infections of the oral cavity and gastrointestinal tract, in particular those caused by the fungus Candida albicans. At low concentrations of miconazole, nitrate interacts with fungal cytochrome P-450, which affects the suppression of the demethylation step in the biosynthesis of ergosterol. The depletion of ergosterol and the concomitant accumulation of lanosterol lead to changes in a number of membrane-related functions. At high concentrations, miconazole interacts with membrane lipids, causing their direct destruction, followed by spreading of the contents of the fungal cell. In Candida albicans, miconazole ultimately inhibits the blastospore into an invasive mycelial form.

Indications

— prevention and treatment in children and adults of candidiasis of the oral cavity and pharynx of various etiologies, in particular, after treatment with antibiotics, corticosteroids, after radio- and chemotherapy and in immunodeficiency states.

Dosage and administration

The drug is recommended to be applied after meals. Infants: ¼ teaspoon 4 times a day.

Children from two years of age and adults: ½ teaspoon 4 times a day.

The drug must be kept in the mouth as long as possible. The course of treatment is 7-14 days.

Contraindications

— hypersensitivity to the ingredients of the drug

— hepatic or renal insufficiency and congenital disorders of the liver.

Precautionary measures:

Side effects

The following adverse reactions have been reported following oral administration of miconazole:

— from the gastrointestinal tract: nausea, vomiting and very rarely diarrhea (usually with long-term treatment).

— from the immune system (very rarely): allergic conditions, including angioedema and anaphylactic reactions; Lyell’s syndrome, Stevens Johnson’s syndrome, urticaria, rash.