Glucophage 1000 mg 30 tablets

Trade name:

Glucophage

Glucophage

Properties

Metformin reduces hyperglycemia without causing hypoglycemia. Unlike sulfonylurea derivatives, it does not stimulate insulin secretion and does not have a hypoglycemic effect in healthy individuals.

Increases the sensitivity of peripheral receptors to insulin and the utilization of glucose by cells. Reduces the production of glucose by the liver by inhibiting gluconeogenesis and glycogenolysis. Delays the absorption of glucose in the intestine.

Metformin stimulates glycogen synthesis by acting on glycogen synthase. Increases the transport capacity of all types of membrane glucose carriers.

Indications

Type 2 diabetes mellitus, especially in obese patients, with the ineffectiveness of diet therapy and physical activity:

— in adults as monotherapy or in combination with other oral hypoglycemic drugs, or with insulin;

— in children from 10 years of age as monotherapy or in combination with insulin.

Dosage and administration

Apply inside.

Adults:

Monotherapy and combination therapy in combination with other oral hypoglycemic agents in type 2 diabetes mellitus.

Contraindications

— hypersensitivity to metformin or to any excipient;

-diabetic ketoacidosis, diabetic precoma, coma;

— renal failure or impaired renal function (CC less than 45 ml / min);

Side effects

Metabolic and nutritional disorders:

Very rarely — lactic acidosis. With long-term use of metformin, there may be a decrease in the absorption of vitamin B12.

Nervous system disorders: