Glucophage 500 mg 50 tablets

Trade name:

Glucophage

Glucophage

Properties

Metformin reduces hyperglycemia without causing hypoglycemia. Unlike sulfonylurea derivatives, it does not stimulate insulin secretion and does not have a hypoglycemic effect in healthy individuals.

Increases the sensitivity of peripheral receptors to insulin and the utilization of glucose by cells. Reduces hepatic glucose production by inhibiting gluconeogenesis and glycogenolysis. Delays the absorption of glucose in the intestine.

Metformin stimulates glycogen synthesis by acting on glycogen synthase. Increases the transport capacity of all types of membrane glucose carriers.

Indications

Type 2 diabetes mellitus, especially in obese patients, with the ineffectiveness of diet therapy and physical activity:

— in adults as monotherapy or in combination with other oral hypoglycemic drugs, or with insulin;

— in children from 10 years of age as monotherapy or in combination with insulin.

Dosage and administration

Take inside.

The usual initial dose is 500 mg or 850 mg 2-3 times / day after or during meals.

Contraindications

— hypersensitivity to metformin or to any excipient;

-diabetic ketoacidosis, diabetic precoma, coma;

— renal failure or impaired renal function (CC less than 45 ml / min);

Side effects

Gastrointestinal disorders:

Very often — nausea, vomiting, diarrhea, abdominal pain, lack of appetite. Most often they occur in the initial period of treatment and in most cases resolve spontaneously. Skin and subcutaneous tissue disorders:

Very rarely — skin reactions such as erythema, itching, rash.