Coveram 10/10mg 15 tablets

Tradename

coveram

Compound:

Each tablet contains:

Perindopril arginine 10 mg

Amlodipine 10 mg

Properties

Combined antihypertensive and antianginal agent, contains perindopril arginine (ACE inhibitor) and amlodipine (calcium channel blocker).

Amlodipine is a slow calcium channel blocker, a derivative of dihydropyridine. Amlodipine inhibits the transmembrane transition of calcium ions into cardiomyocytes and smooth muscle cells of the vascular wall.

Perindopril is an inhibitor of the enzyme that converts angiotensin I to angiotensin II (ACE inhibitor). ACE, or kininase II, is an exopeptidase that both converts angiotensin I to the vasoconstrictor angiotensin II and degrades the vasodilating bradykinin to an inactive heptapeptide.

Indications

Arterial hypertension and / or coronary artery disease (stable angina pectoris) in patients who require therapy with perindopril and amlodipine.

Dosage and administration

The optimal dosing regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed.

On average they take:

Inside, 1 time / day.

Contraindications

Amlodipine

— Severe arterial hypotension (systolic blood pressure less than 90 mm Hg);

-shock (including cardiogenic);

Side effects

From the nervous system: often — drowsiness (especially at the beginning of treatment), dizziness (especially at the beginning of treatment), headache, paresthesia.

From the senses: often — visual disturbances (including diplopia), tinnitus.

From the side of the cardiovascular system: often — a feeling of palpitations, flushes of blood to the skin of the face, a pronounced decrease in blood pressure.