Motilium 10 mg 40 tablets

Tradename

Motilium

Motilium

Compound:

Each tablet contains:

Domperidone maleate 10 mg

Auxiliary components:

Lactose, starch, microcrystalline cellulose, povidone, magnesium stearate, sodium lauryl sulfate, hypromellose.

Properties

Domperidone is a dopamine antagonist with antiemetic properties. Domperidone does not penetrate well through the BBB. The use of domperidone is rarely accompanied by extrapyramidal side effects, especially in adults, but domperidone stimulates the release of prolactin from the pituitary gland. Its antiemetic effect may be due to a combination of peripheral (gastrokinetic) action and antagonism to dopamine receptors in the chemoreceptor trigger zone, which is outside the BBB.

Animal studies and low concentrations of the drug detected in the brain indicate a predominantly peripheral effect of domperidone on dopamine receptors.

Indications

— to relieve symptoms of nausea and vomiting.

Dosage and administration

The drug is taken orally. It is recommended to take Motilium tablets 15-30 minutes before a meal; if the drug is taken after a meal, the absorption of domperidone may slow down.

Adults and adolescents over 12 years of age and children weighing ≥35 kg — 1 tab. (10 mg) 3 times / day, the maximum daily dose is 3 tab. (30 mg).

Contraindications

— hypersensitivity to domperidone or any other component of the drug;

— lactose intolerance, lactase deficiency, glucose-galactose malabsorption;

-prolactinoma;

Side effects

From the immune system: the frequency is unknown — anaphylactic reactions, including anaphylactic shock.

Mental disorders: infrequently — irritability, nervousness.

From the nervous system: often — dizziness; rarely — convulsions; frequency unknown — extrapyramidal disorders.