Pepzol 20 mg 14 tablets

Tradename

Pepzol

pepzol

Compound:

Each capsule contains:

Omeprazole 20 mg

Auxiliary components:

Sodium lauryl sulfate, sodium hydrogen sulfate, calcium carbonate, talc, hypromellose, methacrylic acid copolymer.

Properties

Omeprazole is an antiulcer drug, an inhibitor of the enzyme H + / K + -adenosine triphosphate (ATP) -phase. It inhibits the activity of H + / K + — adenosine triphosphate (ATP-phase (H + / K + -adenosine triphosphate (ATP) -phase, it is also a «proton pump» or «proton pump») in the parietal cells of the stomach, thereby blocking the transfer of ions hydrogen and the final stage of the synthesis of hydrochloric acid in the stomach.Omeprazole is a prodrug.In the acidic environment of the tubules of parietal cells, omeprazole is converted to the active metabolite sulfenamide, which inhibits the membrane H + / K + — adenosine triphosphate (ATP) -phase, connecting to it due to the disulfide bridge This explains the high selectivity of the action of omeprazole specifically on parietal cells, where there is a medium for the formation of sulfenamide.Biotransformation of omeprazole into sulfenamide occurs quickly (after 2-4 minutes).Sulfenamide is a cation and is not absorbed.

Indications

— peptic ulcer of the stomach and duodenum (in the acute phase and anti-relapse treatment), incl. associated with Helicobacter pylori (as part of combination therapy); reflux esophagitis (including erosive). hypersecretory conditions (Zollinger-Ellison syndrome, stress ulcers of the gastrointestinal tract, polyendocrine adenomatosis, systemic mastocytosis);

— gastropathy caused by taking non-steroidal anti-inflammatory drugs.

Dosage and administration

Inside, the capsules are usually taken in the morning, without chewing, with a small amount of water (just before meals).

With exacerbation of peptic ulcer, reflux esophagitis and gastropathy caused by taking NSAIDs — 20 mg 1 time per day. For patients with severe reflux esophagitis, the dose is increased to 40 mg 1 time per day. The course of treatment for duodenal ulcer — 2-4 weeks, if necessary — 4-5 weeks; with gastric ulcer, with reflux esophagitis, with erosive and ulcerative lesions of the gastrointestinal tract caused by taking NSAIDs — within 4-8 weeks.

Contraindications

-childhood;

-pregnancy;

— lactation period;

Side effects

From the digestive system: diarrhea or constipation, abdominal pain, nausea, vomiting, flatulence.

On the part of the skin: rarely — skin rash and / or itching, in some cases photosensitivity, erythema multiforme exudative, alopecia.

Allergic reactions: urticaria, angioedema, fever.