Gliptus plus 50/1000 mg 30 tablets

Trade name:

Glyptus plus

Gliptus plus

Properties

Combined hypoglycemic agent for oral administration.

Vildagliptin, a member of the pancreatic islet stimulant class, selectively inhibits the DPP-4 enzyme, improving glycemic control. Inhibition of DPP-4 activity causes an increase in both basal and postprandial endogenous levels of incretin hormones: glucagon-like peptide type 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).

The use of vildagliptin in patients with type 2 diabetes leads to a rapid and complete inhibition of DPP-4 activity, which is observed for 24 hours.

Indications

Type 2 diabetes mellitus (in combination with diet therapy and exercise): with insufficient effectiveness of monotherapy with vildagliptin or metformin; in patients who previously received combination therapy with vildagliptin and metformin in the form of monodrugs.

Dosage and administration

For oral administration. The dosage regimen is selected individually depending on the effectiveness and tolerability of therapy. When using this combination, the recommended maximum daily dose of vildagliptin 100 mg and metformin hydrochloride 2000 mg should not be exceeded.

Contraindications

— Diabetes mellitus type 1;

— renal failure or severe renal dysfunction with GFR <30 ml / min;

— acute conditions with a risk of developing impaired renal function: dehydration (with diarrhea, vomiting), fever, severe infectious diseases, hypoxia conditions (shock, sepsis, kidney infections, bronchopulmonary diseases);

Side effects

From the nervous system: often — headache, dizziness, tremor. When using vildagliptin in combination with metformin at various doses, hypoglycemia was observed in 0.9% of cases (for comparison, in the placebo group in combination with metformin — in 0.4%).

From the digestive system: often — nausea, gastroesophageal reflux, dysgeusia; infrequently — diarrhea, flatulence; very rarely — hepatitis.

From the side of metabolism and nutrition: very often — loss of appetite; often — hypoglycemia; very rarely — lactic acidosis.