Capozide 50/25mg 30 tablets

Tradename

Capozide

Capozide

Compound:

Each tablet contains:

Captopril 50 mg

Hydrochlorothiazide 25 mg

Auxiliary components:

Microcrystalline cellulose, starch, magnesium stearate, stearic acid, lactose.

Properties

Combined drug, has a hypotensive and diuretic effect.

Captopril is an ACE inhibitor. Reduces the formation of angiotensin II from angiotensin I, reduces the release of aldosterone. Reduces blood pressure, OPSS, afterload, preload. Expands arteries more than veins. Enhances coronary and renal blood flow. With prolonged use, it reduces the severity of myocardial hypertrophy and the walls of resistive arteries; improves blood supply to ischemic myocardium; reduces platelet aggregation.

Hydrochlorothiazide is a medium-strength thiazide diuretic that reduces the reabsorption of sodium ions at the level of the cortical segment of the loop of Henle. Does not affect the acid-base state. It reduces blood pressure by changing the reactivity of the vascular wall, reducing the pressor effect of vasoconstrictor substances (epinephrine, norepinephrine) and increasing the depressant effect on the autonomic ganglia (to a lesser extent, due to a decrease in BCC). Enhances the hypotensive effect of captopril.

Indications

Arterial hypertension (patients who are indicated for combination therapy).

Dosage and administration

The optimal dosing regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed.

It is taken orally at a dose of 50 mg of captopril + 25 mg of hydrochlorothiazide 1 time / day.

Contraindications

Angioedema hereditary or idiopathic (in history while taking ACE inhibitors);

— stenosis of the aortic mouth;

— mitral stenosis;

Side effects

From the respiratory system: often — dry unproductive cough, shortness of breath; very rarely — bronchospasm, eosinophilic pneumonitis, rhinitis, pulmonary edema.

Allergic reactions: often — skin itching, with or without rashes, sometimes accompanied by fever and arthralgia, skin rashes.

From the side of the central nervous system: often — drowsiness, dizziness; rarely — headache, ataxia, paresthesia.