Cordarone 200 mg 30 tablets

Tradename

Kordaron

Cordarone

Compound:

Each tablet contains:

Amiodarone hydrochloride 200 mg.

Auxiliary components:

Lactose, starch, povidone, magnesium stearate.

Properties

Class III antiarrhythmic drug with antianginal activity.

The antiarrhythmic effect is associated with the ability to increase the duration of the action potential of cardiomyocytes and the effective refractory period of the atria, ventricles, AV node, His bundle, Purkinje fibers. This is accompanied by a decrease in the automatism of the sinus node, a slowdown in AV conduction, and a decrease in the excitability of cardiomyocytes.

Indications

Treatment and prevention of paroxysmal arrhythmias: life-threatening ventricular arrhythmias (including ventricular tachycardia), prevention of ventricular fibrillation (including after cardioversion), supraventricular arrhythmias (as a rule, with the ineffectiveness or impossibility of other therapy, especially those associated with WPW syndrome), incl. paroxysm of atrial fibrillation and flutter; atrial and ventricular extrasystole; arrhythmias against the background of coronary insufficiency or chronic heart failure, parasystole, ventricular arrhythmias in patients with Chagas myocarditis; angina.

Dosage and administration

The optimal dosing regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed.

When taken orally for adults, the initial single dose is 200 mg.

Contraindications

Sinus bradycardia, SSS, sinoatrial block, II-III degree AV block (without the use of a pacemaker), cardiogenic shock, hypokalemia, collapse, arterial hypotension, hypothyroidism, thyrotoxicosis, interstitial lung disease, MAO inhibitors, pregnancy, lactation, hypersensitivity to amiodarone and iodine.

Precautionary measures:

Use with caution in chronic heart failure, liver failure, bronchial asthma, in elderly patients (high risk of developing severe bradycardia), under the age of 18 years (efficacy and safety of use have not been established).

Side effects

From the side of the cardiovascular system: sinus bradycardia (refractory to m-anticholinergics), AV blockade, with prolonged use — progression of CHF, ventricular arrhythmia of the «pirouette» type, increased existing arrhythmia or its occurrence, with parenteral use — decrease in blood pressure.

From the endocrine system: the development of hypo- or hyperthyroidism.

From the respiratory system: with prolonged use — cough, shortness of breath, interstitial pneumonia or alveolitis, pulmonary fibrosis, pleurisy, with parenteral use — bronchospasm, apnea (in patients with severe respiratory failure).