Monuril 3 gr 1 sachet

Trade name:

Monuril

Composition

Each sachet contains:

Fosfomycin 3 grams.

Auxiliary components:

sucrose; orange flavor; tangerine flavor; saccharin sodium.

Properties

Broad-spectrum antibiotic derived from phosphonic acid. The mechanism of action is associated with the suppression of the first stage of the synthesis of the bacterial cell wall. Being a structural analogue of phosphoenolpyruvate, competitively irreversibly inhibits the enzyme UDP-N-acetylglucosamienolpyruvyltransferase, which catalyzes the formation reaction of UDP-M-acetyl-3-0- (1-carboxyvinyl) -0-glucosamine from phosphoenolpyruvate and UDP-D-N-acetyl amine … Also fosfomycin is able to reduce the adhesion of bacteria to the mucous membranes of the bladder, which can play the role of a predisposing factor for recurrent infections.

Fosfomycin is active against gram-positive aerobes. Secondary resistance of microorganisms to fosfomycin is rare. There is no cross-resistance with other antibacterial agents. When combined with beta-lactams, fluoroquinolones, glycopeptides or aminoglycosides, there is a pronounced synergism of antimicrobial action against a wide range of gram-positive and gram-negative aerobic bacteria.

Indications

Bacterial urinary tract infections of various localization caused by microorganisms sensitive to fosfomycin:

— acute uncomplicated urinary tract infections; asymptomatic bacteriuria;

— prevention of urinary tract infections after surgery and transurethral diagnostic studies.

Contraindications

Not for use by people weighing less than 50 kg.

Hypersensitivity to fosfomycin or other components of the drug; severe renal failure.

Precautionary measures:

Side effects

From the nervous system: Frequent: headache, dizziness, asthenia.

From the gastrointestinal tract: Not frequent: diarrhea, nausea, dyspepsia.

From the liver and biliary tract: Not frequent: increased activity of «hepatic» transaminases.