Primperan 10 mg 10 tablets

Tradename

Primperan

Primperan

Composition

Each tablet contains:

Metoclopramide hydrochloride 10.00 mg

Auxiliary components:

Lactose monohydrate, microcrystalline cellulose, starch, magnesium stearate.

Properties

Antiemetic, helps to reduce nausea, hiccups; stimulates gastrointestinal motility. The antiemetic effect is due to the blockade of dopamine D2 receptors and an increase in the threshold of the trigger zone chemoreceptors, is a blocker of serotonin receptors. It is believed that metoclopramide inhibits dopamineinduced relaxation of gastric smooth muscl thereby enhancing the cholinergic response gastrointestinal smooth muscles. Helps to accelerate gastric emptying by preventing

relaxation of the stomach body and increasing the activity of the antrum and upper small intestine. Reduces the reflux of the contents into the esophagus by increasing the pressure of the esophageal sphincter at rest and increases the clearance of acid from the esophagus due to an increase in the amplitude of its peristaltic contractions.

Metoclopramide stimulates the secretion of prolactin and causes a transient increase in circulating aldosterone levels, which may be accompanied by short-term fluid retention.

Indications

Vomiting, nausea, hiccups of various origins. Atony and hypotension of the stomach and intestines (including postoperative); biliary dyskinesia; reflux esophagitis; flatulence; as part of the complex therapy of exacerbations of gastric ulcer and duodenal ulcer; acceleration of peristalsis during radiopaque studies of the gastrointestinal tract.

Method of administration and dosage:

For adults inside — 10 mg 1-3 times / day. vomiting, severe nausea, metoclopramide is administered intramuscularly or intravenously

Contraindications

Bleeding from the gastrointestinal tract, mechanical intestinal obstruction, perforation of the stomach or intestines, pheochromocytoma, extrapyramidal disorders, epilepsy, prolactin-dependent tumors, glaucoma, pregnancy, lactation, simultaneous use of anticholinergic drugs, hypersensitivity to metoclopramide.

Precautions:

Use with caution in patients with bronchial asthma, arterial hypertension, impaired liver and / or kidney function, and Parkinson’s disease.

Side effects

From the digestive system: at the beginning of treatment, constipation, diarrhea are possible; rarely dry mouth.

From the side of the central nervous system: at the beginning of treatment, a feeling of fatigue, drowsiness, dizziness, headache, depression, akathisia are possible. It is possible that extrapyramidal symptoms occur in children and young people (even after a single use of metoclopramide): spasm of the facial muscles, hyperkinesis, spastic torticollis (usually disappear immediately after stopping metoclopramide). With prolonged use, more often in elderly patients, parkinsonism and dyskinesia are possible.

From the hematopoietic system: at the beginning of treatment, agranulocytosis is possible.