Dolcil 4 mg 30 tablets

Trade name:

Dolcil

Dolcyl

Composition

Each tablet contains:

Glimepiride 4 mg

Properties

A hypoglycemic drug for oral administration — a third-generation sulfonylurea derivative.

Glimepiride acts mainly by stimulating the secretion and release of insulin from the β-cells of the pancreas (pancreatic action). Like other sulfonylurea derivatives, this effect is based on an increase in the response of β-cells of the pancreas to physiological glucose stimulation, while the amount of secreted insulin is significantly less than with traditional drugs — sulfonylurea derivatives. The least stimulating effect of glimepiride on insulin secretion provides a lower risk of hypoglycemia. In addition to this, glimepiride has an extra-pancreatic effect — the ability to improve the sensitivity of peripheral tissues (muscle, fat) to the action of its own insulin, to reduce the absorption of insulin by the liver; inhibits the production of glucose in the liver. Glimepiride selectively inhibits cyclooxygenase and reduces the conversion of arachidonic acid to thromboxane A2, which promotes platelet aggregation, thus exerting an antithrombotic effect.

Glimepiride contributes to the normalization of lipids, reduces the level of malonic aldehyde in the blood, which leads to a significant decrease in lipid peroxidation, this contributes to the antiatherogenic effect of the drug.

Indications

Treatment of type 2 diabetes mellitus with ineffectiveness of previously prescribed diet and exercise.

If glimepiride monotherapy is ineffective, it can be used in combination therapy with metformin or insulin.

Method of administration and dosage:

Contraindications

— type 1 diabetes mellitus;

— diabetic ketoacidosis,

-diabetic precoma and coma;

Side effects

From the side of metabolism: in rare cases, hypoglycemic reactions may develop. From the side of the organ of vision: during treatment (especially at the beginning), transient visual impairments may occur due to changes in the concentration of glucose in the blood.

On the part of the digestive system: sometimes there may be nausea, vomiting, a feeling of heaviness or discomfort in the epigastrium.

Storage method: