Uricodrop 80 mg 30 tablets

Tradename

Uricodrop 80

Composition

Each tablet contains:

80 mg febuxostat

Auxiliary components:

lactose monohydrate — 76.5 mg, hyprolose — 12 mg, microcrystalline cellulose (Avicel PH101) — 129 mg, microcrystalline cellulose (Avicel PH102) — 172.5 mg, croscarmellose sodium — 25 mg, magnesium stearate — 2.5 mg, water colloidal silicon dioxide — 2.5 mg …

Properties

The enzyme xanthine oxidase catalyzes two stages of purine metabolism: the oxidation of hypoxanthine to xanthine, and then the oxidation of xanthine to uric acid.

The use of febuxostat leads to a more effective reduction in the concentration of uric acid and maintenance of its level in the blood serum compared with allopurinol.

With the use of febuxostat for the prevention and treatment of tumor disintegration syndrome, a more intense and rapid decrease in the concentration of uric acid in the blood serum was observed compared with allopurinol.

Indications

Chronic hyperuricemia in conditions accompanied by the deposition of urate crystals (in the presence of tophus and / or gouty arthritis, including a history).

Treatment and prevention of hyperuricemia in adult patients during cytostatic therapy of hemoblastoses with a moderate to high risk of tumor disintegration syndrome (only for a dosage of 120 mg).

Febuxostat is intended for use in adults.

Contraindications

Pregnancy, breastfeeding period; children under 18 years of age; hypersensitivity to febuxostat.

Precautionary measures:

Febuxostat should only be started after an acute gout attack has subsided. The use of febcostat can provoke the development of an acute attack of gout due to the release of urate from tissue depots and a subsequent increase in the concentration of uric acid in the blood serum. For the prevention of gout attacks, the simultaneous use of NSAIDs or colchicine is recommended for at least 6 months.

Side effects

From the nervous system: often — headache; infrequently — dizziness, paresthesia, hemiparesis, drowsiness, change in taste, hypesthesia, hyposmia (weakening of the sense of smell).

Respiratory system: cough, bronchitis. Hematopoietic system: leukopenia, anemia, thrombocytopenia.

Cardiovascular system: angina pectoris, arrhythmias, arterial hypertension.