Dapoxtard ِ 60 mg 3 tablets

Trade name:

Dapokstard

Dapoxtard

Composition

Each tablet contains:

Dapoxetine 60 mg

Auxiliary components:

Lactose monohydrate, microcrystalline cellulose, carboxymethyl cellulose, aerosil, magnesium stearate, titanium dioxide, polyethylene glycol 6000, talc.

Properties

Dapoxetine is a potent selective serotonin reuptake inhibitor (SSRI) with a half-maximal inhibition concentration (IC50) of 1.12 nM, which is metabolized in the body to the main metabolites — desmethyldapoxetine (IC50 <1.0 nM) and dideoxymethyldapoxetine (IC50 = 2.0 nM), equally or less active (dapoxetine-N-oxide (IC50 = 282 nM)).

The mechanism of action of dapoxetine in premature ejaculation is associated with inhibition of serotonin reuptake by neurons, followed by an increase in the action of a neurotransmitter on pre- and postsynaptic receptors.

The mechanism of ejaculation is regulated mainly by the sympathetic nervous system. In rats, postganglionic sympathetic nerve fibers innervate the seminal vesicles, vas deferens, prostate, urethral and bladder neck muscles, causing them to contract in a coordinated manner to achieve ejaculation. Dapoxetine affects the ejaculation reflex at the supraspinal level in the lateral paragiant cell nuclei, increasing the latency period and reducing the duration of reflex impulses of perineal ganglion motor neurons. The stimulus that triggers ejaculation is generated in the spinal reflex center, which is controlled through the brain stem by several nuclei of the brain, incl. preoptic and paraventricular.

Indications

The drug Dapokstard is intended for the treatment of premature ejaculation in men aged 18 to 64 years.

The drug Dapokstard can only be used in patients who meet the following criteria:

— Intravaginal ejaculation delay time (IVVZE) <2 min;

Contraindications

— hypersensitivity to dapoxetine and / or to any excipient in the preparation;

— severe heart disease;

— simultaneous use of MAO inhibitors and taking dapoxetine within 14 days after stopping the use of an MAO inhibitor;

Side effects

Mental disorders: often — anxiety, agitation, restlessness, unusual dreams, decreased libido.

From the nervous

systems: very often — dizziness, headache; often — drowsiness, impaired concentration, tremor, paresthesia.