Zokor 40 mg 14 tablets

Tradename

Zokor

Zocor

Composition

Each tablet contains:

Simvastatin 40 mg

Auxiliary components:

microcrystalline cellulose, povidone (polyvinylpyrrolidone), citric acid, ascorbic acid, butylhydroxyanisole, corn starch, calcium stearate, hypromellose, macrogol 4000, talc, titanium dioxide.

Properties

A lipid-lowering agent, obtained synthetically from the fermentation product of Aspergillus terreus, is an inactive lactone; it undergoes hydrolysis in the body to form a hydroxy acid derivative. The active metabolite inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase), an enzyme that catalyzes the initial reaction for the formation of mevalonate from HMG-CoA. Since the conversion of HMG-CoA to mevalonate is an early stage in cholesterol synthesis, the use of simvastatin does not cause the accumulation of potentially toxic sterols in the body. HMG-CoA is readily metabolized to acetyl-CoA, which is involved in many synthesis processes in the body.

Causes a decrease in blood plasma triglycerides (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL) and total cholesterol (in cases of heterozygous familial and nonfamilial forms of hypercholesterolemia, with mixed hyperlipidemia, when high cholesterol is a risk factor) … Increases high-density lipoprotein (HDL) and decreases the LDL / HDL ratio and total cholesterol / HDL.

Indications

Hypercholesterolemia:

— primary hypercholesterolemia (type IIa and IIb) with ineffectiveness of diet therapy with low cholesterol content and other non-drug measures (exercise and weight loss) in patients with an increased risk of coronary atherosclerosis;

— combined hypercholesterolemia and hypertriglyceridemia, not corrected by a special diet and physical activity.

Contraindications

— liver disease in the active phase, persistent increase in the activity of liver enzymes of unknown etiology;

— diseases of skeletal muscles (myopathy);

— age up to 10 years (efficacy and safety have not been established);

Side effects

From the digestive system: possible abdominal pain, constipation, flatulence, nausea, diarrhea, pancreatitis, vomiting.

From the side of the central nervous system: asthenic syndrome, headache, dizziness, insomnia.

Dermatological reactions: rarely skin rash, pruritus, alopecia, dermatomyositis.