Specton 25 mg 20 tablets

Tradename

Specton

Spectone

Composition

Each tablet contains:

Spironolactone 25 mg

Properties

Potassium-, magnesium-sparing diuretic. It is a competitive antagonist of aldosterone in terms of its effect on the distal nephron (competes for binding sites on cytoplasmic protein receptors, reduces the synthesis of permeases in the aldosterone-dependent section of the collecting ducts and distal tubules), increases the excretion of Na +, Cl- and water and reduces the excretion of K + and urea, reduces the titratable acidity of urine. Increased diuresis causes a hypotensive effect, which is variable. The antihypertensive effect does not depend on the level of renin in the blood plasma and does not manifest itself at normal blood pressure.

The diuretic effect appears on days 2-5 of treatment.

Indications

Edema in chronic heart failure, cirrhosis of the liver (especially with the simultaneous presence of hypokalemia and hyperaldosteronism), with nephrotic syndrome.

Edema in the II and III trimesters of pregnancy.

Arterial hypertension, incl. with aldosterone-producing adrenal adenoma (as part of combination therapy).

Contraindications

Addison’s disease, hyperkalemia, hypercalcemia, hyponatremia, chronic renal failure, anuria, hepatic failure, diabetes mellitus with confirmed or suspected chronic renal failure, diabetic nephropathy, I trimester of pregnancy, metabolic acidosis, menstrual irregularity or breast enlargement, hypersensitivity …

Precautionary measures:

Use with caution in AV blockade (the possibility of strengthening due to the development of hyperkalemia), decompensated cirrhosis of the liver, surgical interventions, taking drugs that cause gynecomastia, when taking local and general anesthetics, in elderly patients.

Side effects

From the digestive system: nausea, vomiting, abdominal pain, gastritis, ulceration and bleeding in the gastrointestinal tract, intestinal colic, diarrhea or constipation.

From the side of the central nervous system: dizziness, drowsiness, lethargy, headache, lethargy, ataxia.

From the side of metabolism: increased concentration of urea, hypercreatininemia, hyperuricemia, impaired water-salt metabolism and acid base balance (metabolic hypochloremic acidosis or alkalosis).