Daivobet ointment 30 grams

Tradename

Daivobet

Composition

Each gram of ointment contains:

Calcipotriol 50 mg

Betamethasone 0.5 mg

Auxiliary components:

liquid paraffin (contains about 10 ppm alpha-tocopherol), polypropylene glycol stearate (contains about 0.1% butylhydroxytoluene), alpha-tocopherol, white soft paraffin (contains about 10 ppm alpha-tocopherol).

Properties

Combined drug for external use.

Calcipotriol is a synthetic analogue of the active metabolite of vitamin D. It inhibits the proliferation of keratinocytes and accelerates their morphological differentiation.

Betamethasone — GCS for external use; has a local anti-inflammatory, antipruritic, vasoconstrictor and immunosuppressive effect, however, the exact mechanisms of the anti-inflammatory action of topical steroids are not fully understood.

Indications

Chronic vulgar plaque psoriasis.

Method of administration and dosage:

The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.

Contraindications

Diseases accompanied by impaired calcium metabolism; hypersensitivity to any of the components of the drug; severe liver failure; severe renal failure; viral (including herpes or chickenpox), fungal, bacterial and parasitic skin infections; rosacea; rosacea; acne vulgaris; perioral dermatitis; cutaneous manifestations of tuberculosis and syphilis; skin atrophy, skin ulcers; increased fragility of skin vessels; ichthyosis; perianal and genital itching; psoriatic erythroderma; drop-shaped, exfoliative, pustular psoriasis.

Precautionary measures:

The risk of developing hypercalcemia when following the recommended dosage regimen is minimal. However, when used in doses exceeding the recommended maximum weekly dose (100 g), hypercalcemia may develop, which quickly passes when the dose is reduced or canceled.

Side effects

On the part of the skin and skin appendages: frequent — itching, rash, burning sensation; infrequent — pain, irritation, dermatitis, erythema, exacerbation of psoriasis, impaired pigmentation at the site of application of the ointment, folliculitis; rare — pustular psoriasis.

Calcipotriol can cause local skin irritation, itching, burning, acute pain, dry skin, erythema, rash, dermatitis, eczema, and exacerbation of psoriasis.

Long-term topical use of betamethasone (dipropionate) is associated with the development of skin atrophy, telangiectasias, striae, folliculitis, hypertrichosis, perioral dermatitis, allergic contact dermatitis, depigmentation, colloidal degeneration of the skin, as well as an increased risk of developing generalized pustular photosensitivity, hyper- and extremely rare cases of angioedema and facial edema.