Durjoy 60 mg 3 tablets

Trade name:

Durjoy

Compound:

Properties

Dapoxetine is a potent selective serotonin reuptake inhibitor (SSRI) with a half-maximal inhibitory concentration (IC50) of 1.12 nM, metabolized in the body to the main metabolites — desmethyldapoxetine (IC50<1.0 nM) and didesmethyldapoxetine (IC50=2.0 nM), equal or less active (dapoxetine-N-oxide (IC50=282 nM)).

The mechanism of action of dapoxetine in premature ejaculation is associated with inhibition of serotonin reuptake by neurons, followed by an increase in the action of the neurotransmitter on pre- and postsynaptic receptors.

The mechanism of ejaculation is regulated mainly by the sympathetic nervous system. In rats, postganglionic sympathetic nerve fibers innervate the seminal vesicles, vas deferens, prostate, muscles of the urethra, and bladder neck, causing them to contract in a coordinated manner to achieve ejaculation. Dapoxetine affects the ejaculation reflex at the supraspinal level in the lateral paragiant cell nuclei, increasing the latent period and reducing the duration of reflex impulsation of motoneurons in the ganglia of the perineum. The stimulus that triggers ejaculation is generated in the spinal reflex center, which is controlled through the brainstem by several nuclei of the brain, incl. preoptic and paraventricular.

Indications

Durjoy is indicated for the treatment of premature ejaculation in men aged 18 to 64 years.

The drug can only be used in patients who meet the following criteria:

— intravaginal ejaculation delay time (IVVE) <2 min;

Dosage and administration

The recommended starting dose for all men is 30 mg; this dose is taken 1-3 hours before the intended sexual intercourse. In case of insufficient effect and good tolerance of the dose of 30 mg (no moderate or severe adverse reactions or prodromal symptoms that may precede fainting), the dose can be increased to the maximum recommended 60 mg taken 1-3 hours before sexual intercourse. The frequency and severity of adverse reactions increases when taking the drug at a dose of 60 mg.

Contraindications

— hypersensitivity to dapoxetine and / or to any excipient in the composition of the drug;

— severe heart disease;

— simultaneous use of MAO inhibitors and taking dapoxetine within 14 days after stopping the use of an MAO inhibitor;

Side effects

Mental disorders: often — anxiety, agitation, restlessness, unusual dreams, decreased libido.

From the nervous system: very often — dizziness, headache; often — drowsiness, impaired concentration, tremor, paresthesia.

On the part of the organ of vision: often — blurred vision; infrequently — mydriasis, eye pain, visual impairment.