X-Tension 300 mg 28 tablets

Trade name:

Ex-tension (X-tension)

Compound:

Properties

Antihypertensive agent, blocker of angiotensin II (type AT1) receptors.

Reduces the concentration of aldosterone in plasma (does not inhibit kinase II, which destroys bradykinin); eliminates the vasoconstrictor effect of angiotensin II; reduces peripheral vascular resistance, reduces afterload, systemic blood pressure and pressure in the pulmonary circulation. Does not affect the concentration of triglycerides, cholesterol, glucose, uric acid in plasma and the excretion of uric acid.

Indications

-essential hypertension;

— nephropathy in arterial hypertension and type 2 diabetes mellitus (as part of combined antihypertensive therapy).

Dosage and administration

The drug should be taken orally, the tablet is swallowed whole with water. The initial and maintenance dose is 150 mg 1 time / day, regardless of the meal. The use of the drug at this dose provides more optimal 24-hour blood pressure control than at a dose of 75 mg / day. However, in some cases, especially in patients on hemodialysis or in patients over the age of 75 years, the initial dose should be 75 mg.

With insufficient therapeutic effect when using the drug at a dose of 150 mg 1 time / day, the dose can be increased to 300 mg, or another antihypertensive agent should be prescribed. In particular, administration of a diuretic such as hydrochlorothiazide has been shown to enhance the effects of irbesartan.

Contraindications

-pregnancy;

— lactation period;

-children and adolescents under 18 years of age (efficacy and safety have not been established);

Side effects

From the side of the central nervous system: often — dizziness; very rarely — headache.

From the digestive system: often — nausea, vomiting.

On the part of the body as a whole: often — increased fatigue; infrequently — pain in the chest.