Erastapex 40 mg 30 tablets

Tradename

Erastapex (Erastapex)

Compound:

Each tablet contains:

Olmesartan medoxomil 40 mg

Auxiliary components:

Lactose monohydrate, starch, magnesium stearate, talc, titanium dioxide.

Properties

Antihypertensive agent, angiotensin II receptor blocker. It has a high selectivity for angiotensin II type 1 receptors (AT1), with the participation of which the main effects of angiotensin II are realized. By blocking these receptors, olmesartan medoxomil prevents and eliminates the vasoconstrictive effect of angiotensin II, causes a secondary increase in plasma renin activity by eliminating negative feedback on renin release and a direct decrease in aldosterone secretion.

In arterial hypertension, olmesartan medoxomil causes a dose-dependent, prolonged decrease in blood pressure.

Indications

Essential arterial hypertension.

Dosage and administration

Taken orally, daily. The initial dose is 10 mg / day. With insufficient effectiveness, the dose is increased to the optimum — 20 mg / day. If necessary, the dose can be increased to a maximum of 40 mg / day.

For elderly patients, dose adjustment is not required. If it is necessary to increase the daily dose to a maximum of 40 mg / day, the increase should be carried out under careful monitoring of blood pressure.

Contraindications

Obstruction of the biliary tract, pregnancy, breastfeeding, children and adolescents under 18 years of age, hypersensitivity to olmesartan medoxomil.

Precautionary measures:

Due to the lack of sufficient clinical experience, the use of olmesartan medoxomil is not recommended in patients with severe renal insufficiency (CC ≤20 ml / min), in patients with impaired liver function.

Side effects

From the side of the cardiovascular system: arterial hypotension, angina pectoris.

From the hemopoietic system: thrombocytopenia.

From the side of the central nervous system: vertigo, dizziness, headache, asthenic syndrome (fatigue, drowsiness, general malaise).