Capotril 50 mg 20 tablets

Tradename

Capotril

Composition

Each tablet contains:

Captopril 50 mg

Auxiliary components:

Microcrystalline cellulose, talc, magnesium stearate, lactose, sodium glycolate.

Properties

The mechanism of antihypertensive action is associated with competitive inhibition of ACE activity, which leads to a decrease in the rate of conversion of angiotensin I to angiotensin II and eliminates its vasoconstrictor effect.

As a result of a decrease in the concentration of angiotensin II, a secondary increase in plasma renin activity occurs due to the elimination of negative feedback during the release of renin and a direct decrease in aldosterone secretion. Due to its vasodilating action, it reduces the total peripheral vascular resistance (afterload), the pressure of wedging in the pulmonary capillaries (preload) and the resistance in the pulmonary vessels; increases cardiac output and exercise tolerance. Does not affect lipid metabolism.

Indications

-arterial hypertension (including renovascular);

— chronic heart failure (as part of combination therapy).

Method of administration and dosage:

Contraindications

— angioedema, incl. hereditary, history (including history after using other ACE inhibitors);

— severe renal dysfunction, azotemia, hyperkalemia, bilateral renal artery stenosis or stenosis of a single kidney with progressive azotemia, condition after kidney transplantation, primary hyperaldosteronism;

— stenosis of the aortic orifice, mitral stenosis, the presence of other obstacles to the outflow of blood from the left ventricle of the heart;

Side effects

From the side of the cardiovascular system: a marked decrease in blood pressure, tachycardia, orthostatic hypotension, peripheral edema.

From the urinary system: proteinuria, impaired renal function (increased levels of urea and creatinine in the blood).

From the side of the central nervous system: dizziness, headache, ataxia, paresthesia, drowsiness, blurred vision, fatigue, asthenia.