Zolmsolan 2.5 mg 6 pcs

Tradename

Zolmsolan

Compound:

Each mouth-dissolving film contains:

Zolmitriptan 2.5 mg

Auxiliary components:

Polyvinyl alcohol, polyethylene glycol, starch, glycerol, sucrose, menthol oil, simethicone.

Properties

Zolmitriptan is a selective agonist of 5HT1B / 1D receptors, the stimulation of which leads to vasoconstriction. It has a high affinity for recombinant human 5HT1B / 1D receptors and a moderate affinity for 5HT1A receptors. Zolmitriptan has no affinity and does not show significant pharmacological activity in relation to 5HT2-, 5HT3-, 5HT4-, adrenergic, histamine, muscarinic and dopamine receptors.

Zolmitriptan administration to laboratory animals resulted in vasoconstriction in the carotid artery basin. In addition, the results of studies on laboratory animals indicate that zolmitriptan blocks the central and peripheral activity of the trigeminal nerve by inhibiting the release of the peptide associated with the calcitonin gene, vasoactive intestinal peptide and substance P.

In clinical studies, the effect of zolmitriptan on headache and other migraine symptoms (such as nausea, photophobia, phonophobia) was observed after 1 hour and increased in the period from 2 to 4 hours after taking the drug.

Indications

Relief of migraine attacks with or without aura.

Method of administration and dosage:

Stick the film on the surface of the tongue with dry hands.

Contraindications

— hypersensitivity to any components of the drug;

-hemiplegic, basilar and ophthalmoplegic migraine;

-uncontrolled arterial hypertension;

Side effects

From the nervous system: often — disturbances in sensitivity, dizziness, hyperesthesia, paresthesia, drowsiness, a feeling of warmth or cold, vertigo.

From the side of the cardiovascular system: often — a feeling of palpitations.

From the digestive system: often — abdominal pain; nausea, vomiting, dry mouth.