Isoprinosine 500 mg 8 tablets

Trade name:

Isoprinosine (Isoprinosine)

Compound:

Properties

Isoprinosine is a synthetic complex derivative of purine with immunostimulating activity and nonspecific antiviral activity. It restores the functions of lymphocytes under conditions of immunosuppression, increases blastogenesis in the population of monocytic cells, stimulates the expression of membrane receptors on the surface of T-helpers, prevents a decrease in the activity of lymphocyte cells under the influence of glucocorticosteroids, and normalizes the inclusion of thymidine in them. Isoprinosine has a stimulating effect on the activity of cytotoxic T-lymphocytes and natural killers, the function of T-suppressors and T-helpers, increases the production of IgG, interferon gamma, interleukins (IL)-1 and IL-2, reduces the formation of pro-inflammatory cytokines — IL-4 and IL-10, potentiates the chemotaxis of neutrophils, monocytes and macrophages.

The drug exhibits antiviral activity in vivo against Herpes simplex viruses, cytomegalovirus and measles virus, human T-cell lymphoma virus type III, polioviruses, influenza A and B, ECHO virus (human enterocytopathogenic virus), encephalomyocarditis and equine encephalitis. The mechanism of the antiviral action of Isoprinosine is associated with the inhibition of viral RNA and the enzyme dihydropteroate synthetase, which is involved in the replication of some viruses. It enhances the synthesis of lymphocyte mRNA suppressed by viruses, which is accompanied by suppression of viral RNA biosynthesis and translation of viral proteins, increases the production of alpha and gamma interferons by lymphocytes, which have antiviral properties.

With a combined appointment, it enhances the effect of interferon alfa, antiviral agents acyclovir and zidovudine.

Indications

-treatment of influenza and other acute respiratory viral infections;

— infections caused by Herpes simplex virus types 1, 2, 3 and 4:

— genital and labial herpes, herpetic keratitis;

Dosage and administration

Tablets are taken after meals with a small amount of water.

The recommended daily dose for adults and children aged 3 years and older (with a body weight of 15-20 kg) is 50 mg / kg of body weight in 3-4 doses (for adults — 6-8 tablets / day, for children — 1/2 tablet per 5 kg of body weight / day).

In severe forms of infectious diseases, the dose can be increased individually to 100 mg / kg body weight / day, divided into 4-6 doses. The maximum daily dose for adults is 3-4 g / day, for children — 50 mg / kg / day.

Contraindications

-urolithiasis disease;

-gout;

— arrhythmias;

Side effects

From the gastrointestinal tract: often — nausea, vomiting, epigastric pain; sometimes — diarrhea, constipation.

From the side of the liver and biliary tract: often — a temporary increase in the activity of transaminases and alkaline phosphatase in the blood plasma, an increase in the concentration of urea in the blood plasma.

Dermatological reactions: often — itching.