Trillerg eye drops 10 ml

Tradename

Trillerg

Compound:

Each 1 ml of solution contains:

Antazolin hydrochloride 0.5 mg

Tetrizoline hydrochloride 0.4 mg

Benzalkonium chloride 0.05 mg as a preservative.

Properties

Combined antiallergic drug for topical use in ophthalmology, containing a blocker of histamine H1 receptors and an alpha-agonist.

Antazolin is a selective blocker of histamine H1 receptors, a representative of the group of ethylenediamines. When used systemically, histamine H1 receptor blockers from the ethylenediamine group, despite a slight effect on the central nervous system, can have a moderate sedative effect, as well as cause gastric disorders and skin sensitization. By competitively blocking histamine H1 receptors, antazoline reduces histamine-induced spasms of smooth muscles, increased permeability, and dilated capillaries. Histamine H1 receptor blockers effectively eliminate itching, but slightly reduce the severity of hyperemia.

Tetrizoline is a sympathomimetic. By stimulating α-adrenergic receptors, it causes constriction of peripheral vessels, reduces hyperemia and swelling of the conjunctiva in patients with allergic conjunctivitis. It was shown that a positive clinical effect develops 1-5 minutes after instillation of tetrizoline, persists for an average of 1-4 hours (up to a maximum of 8 hours).

Indications

Allergic diseases of the conjunctiva: — to reduce the severity of symptoms of allergic conjunctivitis, eliminate hyperemia and edema of the conjunctiva of the eye, itching in adults and children over 2 years old.

Dosage and administration

For adults and adolescents, the drug should be instilled into the conjunctival sac, 1 drop 2-3 times a day for no more than 14 days.

Special clinical studies on the use of Trillerg drops in children over 2 years of age have not been conducted. Since the drug can have a systemic effect, children over 2 years old should not be instilled more than 1-2 drops 1 time / day. Thrillerg should not be used for more than 14 days, because. with prolonged use of the drug, toxic follicular conjunctivitis and reactive hyperemia of the conjunctiva can be observed.

Pressing the lower lacrimal opening or closing the eyes for 3 minutes after instillation into the conjunctival sac reduces the entry of drops into the systemic circulation, which contributes to a more effective local action of the drug and a decrease in the incidence of systemic side effects.

Contraindications

— hypersensitivity to the components of the drug;

-simultaneous use with MAO inhibitors.

Precautionary measures:

Side effects

On the part of the organ of vision: most often — temporary mild or moderate burning of the eyes.

From the side of the central nervous system and peripheral nervous system: headache, lethargy, drowsiness, dizziness, tremor and agitation.

From the side of the cardiovascular system: angina pectoris, hypertension and tachycardia.