Inegy 10 mg/20 mg 14 tablets

Tradename

Inegy

Compound:

Each tablet contains:

ezetimibe 10 mg

simvastatin 20 mg

Auxiliary components:

lactose monohydrate, microcrystalline cellulose, hypromellose, croscarmellose sodium, citric acid monohydrate, butylhydroxyanisole, propyl gallate, magnesium stearate.

Properties

Combined lipid-lowering agent that reduces the absorption of cholesterol and related plant sterols in the intestine, and also suppresses endogenous cholesterol synthesis.

Simvastatin reduces both elevated and normal LDL levels. LDL is formed from VLDL and is cleaved predominantly by the high-affinity LDL receptor. The decrease in LDL after taking simvastatin leads to a decrease in the content of VLDL and activation of LDL receptors, which leads to a decrease in the formation and increased catabolism of LDL. With simvastatin therapy, ApoB levels also decrease. In addition, simvastatin modestly increases HDL levels and reduces plasma TG. As a result of these changes, total cholesterol and LDL levels decrease.

ezetimibe

Indications

Primary hypercholesterolemia: heterozygous (familial and non-familial) hypercholesterolemia or mixed hyperlipidemia (as an adjunct to a diet to reduce total cholesterol, LDL, apolipoprotein B, triglycerides, low density lipoproteins, to increase HDL levels);

homozygous familial hypercholesterolemia: to reduce elevated levels of total cholesterol and LDL (both as an adjunct to other lipid-lowering therapy, such as LDL apheresis, and in its absence).

Dosage and administration

Inside 1 time / day. The dosage regimen is individual, depending on the indications, the age of the patient and the clinical situation.

Contraindications

Liver disease in the active phase or a persistent increase in the activity of hepatic transaminases of unclear etiology;

— moderate and severe liver failure (7 or more points on the Child-Pugh scale);

-pregnancy;

Side effects

From the digestive system: flatulence, abdominal pain, constipation, diarrhea, dyspepsia, vomiting, cholelithiasis, cholecystitis, jaundice, hepatitis; nausea; pancreatitis; in some cases — liver failure.

From the hemopoietic system: thrombocytopenia, anemia.

From the musculoskeletal system: arthralgia, muscle weakness, muscle spasms, neck pain, pain in the extremities.